Icariside B1 is a megastigmane glycoside compound isolated from Petasites tricholobus Franch, with an anticancer effect[1][2].
Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat induces dopamine release in the rat striatum in vivo and in vitro, and it exerts a very strong chemotactic effect on monocytes and eosinophils but not on granulocytes[1].
Alvimopan metabolite-d5 is the deuterium labeled Alvimopan Metabolite[1].
Glutamic acid dimethyl ester hydrochloride is a glutamic acid derivative[1].
Etomoxir ((R)-(+)-Etomoxir) is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
(R)-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer[1][2].
MRGPRX1 agonist 2 (compound 1a) is a potent Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.48 μM. MRGPRX1 agonist 2 can be used for researching neuropathic pain[1].
2-((2-Aminoethyl)amino)acetic acid is a Glycine (HY-Y0966) derivative[1].
6'-O-trans-Feruloylnodakenin is a marker compound used for HPLC fingerprint of N. forbesii[1].
Antitumor agent-2 is sourced from patent CN102250203, compound 6a-r, has antitumor action and anti-inflammatory action[1].
Dipentamethylenethiuram Tetrasulfide is a material for constructing rubber (extracted from patent CN112876756A)[1].
4,15-Isoatriplicolide methylacrylate is a germacrane-type sesquiterpene lactone. 4,15-Isoatriplicolide methylacrylate also is a cytotoxic agent. 4,15-Isoatriplicolide methylacrylate has cytotoxic activity for MCF-7 human breast cancer cell line[1].
SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK[1].
Tranexamic acid-d2-1 is the deuterium labeled Tranexamic acid[1]. Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM[2][3].
NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory drug for the treatment of skin inflammation.
SEluc-2 is a small-molecule probe based on the firefly luciferin. SEluc-2, a bioluminescent probe for the sensitive and selective detection of thiols in living cells[1].
7-Xylosyl-10-Deacetyltaxol C (7-Xylosyl-10-Deacetylpaclitaxel C) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol C has anti-tumor activity and inhibits the growth of S180 sarcoma[1].
Etofylline clofibrate has ypolipidemic and antithrombotic effect. Etofylline clofibrate has an agonistic interaction with intimal PGI2[1].
Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1].
N-Acetyl-DL-histidine Monohydrate is a histidine derivative[1].
3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.
Thialysine (hydrochloride) is a cysteine derivative[1].
Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism [1][2][3].
N-Valerylglycine is a Glycine (HY-Y0966) derivative[1].
(Rac)-3-Hydroxyphenylglycine is an phosphoinositide hydrolysis agonist[1]. ACPD: I-aminocyclopcntane-1,3-dicarboxylic acid.
Fmoc-Asp(ODMAB)-OH is an aspartic acid derivative[1].
POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].
((3-Fluorophenyl)sulfonyl)-L-leucine is a leucine derivative[1].
Pulmonary arterial hypertension agent-1 (example 15) is a pulmonary arterial hypertension agent[1].
Tegoprubart is a monoclonal antibody directed against CD40 ligand (CD40L), a key mediator of costimulation. Inhibition of CD40L reduces cellular and antibody-mediated immunity and creates a more tolerant immune environment. Tegoprubart was demonstrated to have in vivo efficacy in transplantation animal models.