12141-67-2

12141-67-2 structure

Name: POM 1
Chemical Name: sodium metatungstate
CAS Number: 12141-67-2
Molecular Formula: H₂Na₆O₄₀W₁₂
Molecular Weight: 2986.01
Catalog: analytical chemistry Standard Spectrometric standard
Create Date: 2018-09-18 11:51:47
Modify Date: 2024-01-02 13:18:01
POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].

Name	sodium metatungstate
Synonyms	SODIUM POLYTUNGSTATE POM 1 4-Acetyl-1,1-dimethylpiperazinium iodide Sodium metatungstate monohydrate EINECS 412-770-9 Sodium metatungstate SODIUM POLYTINGSTATE hexasodium tungstate hydrate Sodium polytungstate solution TUNGSTATEHEXASODIUM MFCD00061466

Description	POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1].
References	[1]. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7. [2]. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8.

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H318-H412
Precautionary Statements	P273-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	26-39-61
RIDADR	NONH for all modes of transport
WGK Germany	2