Tranexamic acid-d2-1

Modify Date: 2024-01-02 18:21:59

Tranexamic acid-d2-1 Structure
Tranexamic acid-d2-1 structure
Common Name Tranexamic acid-d2-1
CAS Number 2714435-89-7 Molecular Weight 159.22
Density N/A Boiling Point N/A
Molecular Formula C8H13D2NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tranexamic acid-d2-1


Tranexamic acid-d2-1 is the deuterium labeled Tranexamic acid[1]. Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM[2][3].

 Names

Name Tranexamic acid-d2-1

 Tranexamic acid-d2-1 Biological Activity

Description Tranexamic acid-d2-1 is the deuterium labeled Tranexamic acid[1]. Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Bhat A, et al. Tranexamic acid overdosage-induced generalized seizure in renal failure. Saudi J Kidney Dis Transpl. 2014 Jan-Feb;25(1):130-2.  

[3]. Couturier R, et al. Continuous or discontinuous tranexamic acid effectively inhibits fibrinolysis in children undergoing cardiac surgery with cardiopulmonary bypass. Blood Coagul Fibrinolysis. 2014 Jan 13.  

 Chemical & Physical Properties

Molecular Formula C8H13D2NO2
Molecular Weight 159.22