Fmoc-Phe-Lys(Boc)-PAB-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Sulfo-SPDB linker is a disulfide-cleavable linker used for the antibody-drug conjugate (ADC)[1].
Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Propargyl-PEG1-SS-PEG1-propargyl is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
m-PEG4-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
BCOT-PEF3-OPFP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Acid-propionylamino-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Azidoethyl-SS-ethylazide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody drug conjugate linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Fmoc-(D-Phe)-Osu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[1].
DC1-Sme is an antibody conjugate of phosphate prodrug of cytotoxic DNA alkylators for the targeted treatment of cancer.
6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- is an useful linker for antibody-drug-conjugations (ADCs), extracted from [Bioorg Chem. 2012 Apr-Jun;41-42:1-5.] compound 1i.
m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Endo-BCN-Fmoc-L-Lysine is a linker containing the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Z-AEVD-FMK is a cleavable ADC linker for the synthesis of antibody active molecule conjugates (ADCs).
Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker that can be used to synthesize antiboy-drug Conjugates (ADCs).
MC-VA-Modified PABC is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates[1].
Bis-PEG1-PFP ester is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule[1].