883554-11-8

883554-11-8 structure

Name: m-PEG4-Boc
Chemical Name: tert-Butyl 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propionate
CAS Number: 883554-11-8
Molecular Formula: C₁₄H₂₈O₆
Molecular Weight: 292.36900
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-04-01 13:30:16
Modify Date: 2025-09-26 13:51:01
m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	tert-Butyl 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propionate
Synonyms	tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate

Description	m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1. [2]. Peter Madsen, et al. Protease stabilized, pegylated insulin analogues. WO2009010428A1.