m-PEG4-Boc
Modify Date: 2024-01-10 10:49:18
m-PEG4-Boc structure
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Common Name | m-PEG4-Boc | ||
|---|---|---|---|---|
| CAS Number | 883554-11-8 | Molecular Weight | 292.36900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H28O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of m-PEG4-Bocm-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
| Name | tert-Butyl 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propionate |
|---|---|
| Synonym | More Synonyms |
| Description | m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
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| Related Catalog | |
| Target |
PEGs Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
[2]. Peter Madsen, et al. Protease stabilized, pegylated insulin analogues. WO2009010428A1. |
| Molecular Formula | C14H28O6 |
|---|---|
| Molecular Weight | 292.36900 |
| Exact Mass | 292.18900 |
| PSA | 63.22000 |
| LogP | 1.41440 |
| Storage condition | 2-8°C |
| tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate |