m-PEG4-O-NHS ester

Modify Date: 2024-01-30 17:24:09

m-PEG4-O-NHS ester Structure
m-PEG4-O-NHS ester structure
Common Name m-PEG4-O-NHS ester
CAS Number 147912-03-6 Molecular Weight 349.33400
Density N/A Boiling Point N/A
Molecular Formula C14H23NO9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of m-PEG4-O-NHS ester


m-PEG4-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 11-methoxy-3,6,9-trioxaundecanyl N-succinimidyl carbonate
Synonym More Synonyms

 m-PEG4-O-NHS ester Biological Activity

Description m-PEG4-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C14H23NO9
Molecular Weight 349.33400
Exact Mass 349.13700
PSA 109.83000

 Synonyms

carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester