Mal-amido-PEG4-NHS ester

Modify Date: 2024-01-03 21:11:26

Mal-amido-PEG4-NHS ester Structure
Mal-amido-PEG4-NHS ester structure
Common Name Mal-amido-PEG4-NHS ester
CAS Number 756525-99-2 Molecular Weight 513.49500
Density 1.36±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H31N3O11 Melting Point N/A
MSDS USA Flash Point N/A

 Use of Mal-amido-PEG4-NHS ester


Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Synonym More Synonyms

 Mal-amido-PEG4-NHS ester Biological Activity

Description Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.36±0.1 g/cm3
Molecular Formula C22H31N3O11
Molecular Weight 513.49500
Exact Mass 513.19600
PSA 170.57000

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Synonyms

monodisperse Mal-PEG4-NHS-ester
AmbotzPEG1575
Maleimide-PEG4-NHS Ester
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