m-PEG4-Boc

Names

[ Name ]:
m-PEG4-Boc

[Synonym ]:
tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate

Biological Activity

[Description]:

m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1.

[2]. Peter Madsen, et al. Protease stabilized, pegylated insulin analogues. WO2009010428A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₈O₆

[ Molecular Weight ]:
292.36900

[ Exact Mass ]:
292.18900

[ PSA ]:
63.22000

[ LogP ]:
1.41440

[ Storage condition ]:
2-8°C

Related Compounds

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