Pro-Phe-Phe is the most aggregation-prone tripeptide of natural amino acids. Pro-Phe-Phe forms unique helical-like sheets that mate via aromatic dry interfaces. Pro-Phe-Phe can be used for the design of modular super-helical self-assembling nanostructures[1][2].
Cefacetrile (Cephacetrile) is a broad-spectrum antibiotic that is effective in gram-positive and gram-negative bacterial infection[1][2].
Poly(ethylene glycol) dithiol (Mn 3400) is a polymer and can be used as a biomaterial to prepare hydrogels[1].
DMNQ is a redox cycling agent that generates both superoxide and hydrogen peroxide intracellularly in a concentration dependent manner. DMNQ increases ROS generation[1].
Zelenectide (BCY8116) is a Bicycle peptide targeting to Nectin-4, which is a cell adhesion molecule. Zelenectide serves as a Bicycle tumor-targeted immune cell agonist[1].
ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.
Boc-Tyr(3,5-I2)-OSu is a tyrosine derivative[1].
N,N-Dimethylformamide (DMF) is widely used as a drug solvent. N,N-Dimethylformamide is a dipolar protophilic solvent with physicochemical properties that makes it suitable as solvent for capillary electrophoresis (CE)[1][2].
H-Cys(pMeOBzl)-OH is a cysteine derivative[1].
BnO-PEG4-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Collinin is a anti-tubercular agent, it can be isolated from leaves of Z. schinifolium. Collinin has an excellent anti-tuberculosis effect against multidrug-resistant (MDR), extensively drug-resistant (XDR) strains[1].
Eleutheroside D is an active lignan isolated from the root of Eleutherococcus senticosus, has anti-inflammatory and hypoglycemic activities[1]. Eleutheroside D is an optical isomer of Eleutheroside E (HY-N0272)[2].
CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
MRS2698 is a potent and highly selective P2Y2 receptor agonist with an EC50 of 8 nM. MRS2698 is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 receptors[1][2].
viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. viFSP1 targets the highly conserved NAD(P)H binding pocket of FSP1 and directly inhibits FSP1. viFSP1 induces lipid peroxidation and has anticancer activity[1].
Saredutant is a selective NK2 receptor antagonist.
Activated C Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy[1].
Chlorthal-dimethyl used as a pesticide intermediate.
Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities[1].
Oxazosulfyl is a potent agricultural fungicide. Oxazosulfyl can be used as an insecticide against major rice pests[1].
Temocapril-d5 is the deuterium labeled Temocapril. Temocapril is an angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases[1][2].
OxyMetazoline is an α-adrenoceptor agonist with IC50s of 0.02 μM, 0.25 μM, 0.58 μM and 0.13 μM for α1A, α1B, α2A and α2C. OxyMetazoline can be used for researching nasal mucosa decongesting[1].
Z-Pro-Pro is a peptide[1].
Meridinol ((-)-Meridinol) shows antimicrobial activity against a wide range of gram-positive and gram-negative bacteria and fungi.
Docosahexaenoyl glycine is a PUFA analogue. Docosahexaenoyl glycine has activating effects on IKs?channels?and restore the function of IKs?channels with LQT1 mutation[1].
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation[1].
Evacetrapib is a potent and selective of CETP inhibitor, which inhibits human recombinant CETP protein (IC50 5.5 nM) and CETP activity in human plasma (IC50 36 nM) in vitro.
t-Boc-Aminooxy-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Filanesib (ARRY-520) is a synthetic kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.