1491-59-4

1491-59-4 structure

1491-59-4 structure

Name: Oxymetazoline
Chemical Name: oxymetazoline
CAS Number: 1491-59-4
Molecular Formula: C₁₆H₂₄N₂O
Molecular Weight: 260.37500
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-02-20 08:00:00
Modify Date: 2024-01-06 20:03:09
OxyMetazoline is an α-adrenoceptor agonist with IC50s of 0.02 μM, 0.25 μM, 0.58 μM and 0.13 μM for α1A, α1B, α2A and α2C. OxyMetazoline can be used for researching nasal mucosa decongesting[1].

Name	oxymetazoline
Synonyms	Oximetazolinum EINECS 216-079-1 Rhinofrenol 3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-6-tert-butylphenol MFCD00242798 Iliadin Oxymethazoline 2-(4-t-butyl-2,6-dimethyl-3-hydroxy-benzyl)-2-imidazoline Sinerol 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol Oxylazine Nezeril Hazol Nafrine

Description	OxyMetazoline is an α-adrenoceptor agonist with IC50s of 0.02 μM, 0.25 μM, 0.58 μM and 0.13 μM for α1A, α1B, α2A and α2C. OxyMetazoline can be used for researching nasal mucosa decongesting[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	IC50: 0.02 μM (α1A), 0.25 μM (α1B), 0.58 μM (α2A), 0.13 μM (α2C)[1]
References	[1]. Haenisch B, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

Density	1.08 g/cm3
Boiling Point	431.9ºC at 760 mmHg
Melting Point	182ºC
Molecular Formula	C₁₆H₂₄N₂O
Molecular Weight	260.37500
Flash Point	215ºC
Exact Mass	260.18900
PSA	44.62000
LogP	2.61510
Vapour Pressure	4.59E-08mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK1050000

CHEMICAL NAME :: Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-

CAS REGISTRY NUMBER :: 1491-59-4

BEILSTEIN REFERENCE NO. :: 0886303

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H24-N2-O

MOLECULAR WEIGHT :: 260.42

WISWESSER LINE NOTATION :: T5M CN BUTJ B1R CQ B1 F1 DX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,74,1967 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,563,1975

RIDADR	UN 3249
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2933290090

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%