1491-59-4

• 常用中文名：羟甲唑啉
• 常用英文名：Oxymetazoline
• CAS号：1491-59-4
• 分子式：C₁₆H₂₄N₂O
• 分子量：260.37500
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 肾上腺素能受体
• 发布时间：2018-02-20 08:00:00
• 更新时间：2024-01-06 20:03:09
• 羟甲唑啉是一种α-肾上腺素受体激动剂,α1A、α1B、α2A和α2C的IC50s分别为0.02μM、0.25μM、o.58μM和0.13μM。奥昔他唑啉可用于研究鼻粘膜的解充血作用[1]。

名称

• 中文名: 羟甲唑啉
• 英文名: oxymetazoline
• 中文别名: 2-(3-羟基-2,6-二甲基-4-叔丁基苄基)-2-咪唑啉; 氧甲唑啉; 阿弗林; 6-叔丁基-3-(4,5-二氢-1H-咪唑-2-基甲基)-2,4-二甲基苯酚; [羟间唑啉]
• 英文别名: Oximetazolinum; EINECS 216-079-1; Rhinofrenol; 3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-6-tert-butylphenol; MFCD00242798; Iliadin; Oxymethazoline; 2-(4-t-butyl-2,6-dimethyl-3-hydroxy-benzyl)-2-imidazoline; Sinerol; 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol; Oxylazine; Nezeril; Hazol; Nafrine

物化性质

• 密度: 1.08 g/cm3
• 沸点: 431.9ºC at 760 mmHg
• 熔点: 182ºC
• 分子式: C₁₆H₂₄N₂O
• 分子量: 260.37500
• 闪点: 215ºC
• 精确质量: 260.18900
• PSA: 44.62000
• LogP: 2.61510
• 蒸汽压: 4.59E-08mmHg at 25°C

生物活性

• 描述: 羟甲唑啉是一种α-肾上腺素受体激动剂,α1A、α1B、α2A和α2C的IC50s分别为0.02μM、0.25μM、o.58μM和0.13μM。奥昔他唑啉可用于研究鼻粘膜的解充血作用[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
• 靶点:

  IC50: 0.02 μM (α1A), 0.25 μM (α1B), 0.58 μM (α2A), 0.13 μM (α2C)[1]

• 参考文献:

  [1]. Haenisch B, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SK1050000 CHEMICAL NAME : Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl- CAS REGISTRY NUMBER : 1491-59-4 BEILSTEIN REFERENCE NO. : 0886303 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C16-H24-N2-O MOLECULAR WEIGHT : 260.42 WISWESSER LINE NOTATION : T5M CN BUTJ B1R CQ B1 F1 DX1&1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2700 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,74,1967 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 20 mg/kg SEX/DURATION : female 1-5 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,563,1975

安全

• 危险品运输编码: UN 3249
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 2933290090

海关

海关编码	2933290090
中文概述	2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%