ERB-196

Modify Date: 2024-01-11 18:14:45

ERB-196 structure	Common Name	ERB-196
	CAS Number	550997-55-2	Molecular Weight	279.26500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₀FNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ERB-196

ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.

Name	3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthalene-1-carbonitrile
Synonym	More Synonyms

Description	ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Neurological Disease Research Areas >> Inflammation/Immunology
Target	ERβ[1]
In Vivo	ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. ERB-196 significantly reduces histopathologic evidence of injury to the gastrointestinal mucosal surface (0.7±0.1 vs. 2.3±0.2 for control; p<0.05). The mucosal mass of 10-cm segments of small bowel mucosa shows better preservation of mucosal mass than control treatment (63±20 [ERB-196] vs. 31±24 [control]), but this difference fails to reach statistical significance (p<0.06). The administration of ERB-196 is highly effective in the prevention of lethality. Consistent with the neutropenic rat model, ERB-196 significantly increases survival when compare with vehicle control[1].
Animal Admin	The neutropenic rat model of pseudomonas sepsis are used in this study. For the survival study, ERB-196 (50 mg/kg; n=12) or vehicle control (n=8) is administered daily by orogastric feeding beginning on day 4 after the first dose of cyclophosphamide and continuing for 8 days. Animals are assessed clinically and pathologically by measuring daily body weight, body temperature, presence of bacteremia, circulating endotoxin levels, and pathologic evidence of damage to the gastrointestinal epithelium and liver by light microscopy and electron microscopy. Blood and tissue samples are serially diluted in sterile saline and incubated at 37°C on pseudomonas agar for quantitative assessment of bacterial concentrations[1].
References	[1]. Cristofaro PA, et al. WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Crit Care Med. 2006 Aug;34(8):2188-93.

Molecular Formula	C₁₇H₁₀FNO₂
Molecular Weight	279.26500
Exact Mass	279.07000
PSA	64.25000
LogP	3.92878
Storage condition	2-8℃

di-tert-butyl (...

CAS#:1049684-42-5

ERB-196

CAS#:550997-55-2

Literature: WYETH Patent: US2008/214507 A1, 2008 ; Location in patent: Page/Page column 5-6 ;

7-Methoxy-1-tet...

CAS#:6836-19-7

ERB-196

CAS#:550997-55-2

Literature: Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A. Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979

7-methoxy-3,4-d...

CAS#:158365-53-8

ERB-196

CAS#:550997-55-2

3-(3-fluoro-4-m...

CAS#:550998-36-2

ERB-196

CAS#:550997-55-2

3-BROMO-7-HYDRO...

CAS#:550998-30-6

ERB-196

CAS#:550997-55-2

7-HYDROXY-1-NAP...

CAS#:19307-13-2

ERB-196

CAS#:550997-55-2

7-METHOXY-1-NAP...

CAS#:158365-54-9

ERB-196

CAS#:550997-55-2

3-(3-fluoro-4-m...

CAS#:550998-36-2

Pyridine chlorh...

CAS#:628-13-7

~71%

ERB-196

CAS#:550997-55-2

Literature: Wyeth Patent: US2003/181519 A1, 2003 ;

Precursor 8
CAS#:1049684-42-5 di-tert-butyl (... CAS#:6836-19-7 7-Methoxy-1-tet... CAS#:158365-53-8 7-methoxy-3,4-d... CAS#:550998-36-2 3-(3-fluoro-4-m...
CAS#:550998-30-6 3-BROMO-7-HYDRO... CAS#:19307-13-2 7-HYDROXY-1-NAP... CAS#:158365-54-9 7-METHOXY-1-NAP... CAS#:628-13-7 Pyridine chlorh...
DownStream 0

3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE

1yye

3-(3-fluoro-4-hydroxy-phenyl)-7-hydroxy-naphthalene-1-carbonitrile

1-Naphthalenecarbonitrile,3-(3-fluoro-4-hydroxyphenyl)-7-hydroxy

ERB-196

ERB-196

Use of ERB-196

Names

ERB-196 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms