7-Methoxy-1-tetralone

Modify Date: 2025-08-21 12:38:42

7-Methoxy-1-tetralone structure	Common Name	7-Methoxy-1-tetralone
	CAS Number	6836-19-7	Molecular Weight	176.21
	Density	1.1±0.1 g/cm3	Boiling Point	312.3±31.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₂O₂	Melting Point	59-63 °C(lit.)
	MSDS	Chinese USA	Flash Point	145.8±18.4 °C

Use of 7-Methoxy-1-tetralone

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1].

Name	7-Methoxy-1-tetralone
Synonym	More Synonyms

Description	7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
In Vitro	7-Methoxy-1-tetralone (31.25-1000 μM; 48 h) 抑制 LO2 和 HepG2 细胞的增殖活性[1]。 7-Methoxy-1-tetralone (40 μM, 100 μM, 250 μM; 48 h) 诱导 HepG2 细胞凋亡，调节细胞中 c-Met、p-AKT、AKT、NF-κB、MMP2、MMP9 蛋白的表达水平[1]。 Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 40 μM, 100 μM, and 250 μM Incubation Time: 48 h Result: Decreased the protein expression levels of c-Met, p-AKT, NF-κB, MMP2, and MMP9. Cell Proliferation Assay[1] Cell Line: LO2 and HepG2 cells Concentration: 31.25 μM, 62.5 μM, 125 μM, 250 μM, 500 μM, and 1000 μM Incubation Time: 24 h, 48 h, and 72 h Result: Exhibited anti-proliferative activity of MT on LO2 and HepG2 cells.
In Vivo	7-Methoxy-1-tetralone (80, 120, or 160 mg/kg/d；腹腔注射；共 19 次剂量) 抑制 HepG2 细胞皮下植入肿瘤模型的肿瘤生长[1]。 Animal Model: BALB/c nude mice (5-week-old) with subcutaneously implanted HepG2 cells[1] Dosage: 80, 120, or 160 mg/kg/d Administration: Intraperitoneal injection; sacrificed after 19 days Result: Resulted the tumor inhibition rates of 40.57% (80 mg/kg), 51.43% (120 mg/kg), 79.43% (160 mg/kg), respectively.
References	[1]. Wen Y, et al. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Front Oncol. 2020 Feb 7;10:58.

Density	1.1±0.1 g/cm3
Boiling Point	312.3±31.0 °C at 760 mmHg
Melting Point	59-63 °C(lit.)
Molecular Formula	C₁₁H₁₂O₂
Molecular Weight	176.21
Flash Point	145.8±18.4 °C
Exact Mass	176.083725
PSA	26.30000
LogP	2.79
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.549
Storage condition	2~8°C

7-Methoxy-1-tetralone MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2914509090

Precursor 9
CAS#:4521-28-2 4-(4-Methoxyphe... CAS#:32820-10-3 7-Methoxy-1,2,3... CAS#:1730-48-9 Naphthalene,1,2... CAS#:106336-27-0 (7-methoxy-1,2,...
CAS#:6836-18-6 4-(4-Methoxyphe... CAS#:87543-05-3 1,1-(1,2-Benzen... CAS#:666177-27-1 dimethyl 1,2-di... CAS#:3153-44-4 4-(4-Methoxyphe...
CAS#:87543-11-1 1-(4,4-(1,2-Ben...
DownStream 10
CAS#:31846-36-3 7-HYDROXY-1,2,3... CAS#:4133-34-0 7-Methoxy-3,4-d... CAS#:22246-83-9 8-METHOXY-4,5-D... CAS#:22246-71-5 8-Methoxy-2,3,4...
CAS#:19393-87-4 8-Methyl-2-naphthol CAS#:19307-13-2 7-HYDROXY-1-NAP... CAS#:30021-91-1 6-methoxy-4-met... CAS#:26593-50-0 7-Methyl-2-naphthol
CAS#:2800-94-4 2-(hydroxymethy... CAS#:861960-34-1 7-Methoxy-3,4-d...

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

The reaction of 1-tetralones with thallium trinitrate supported on clay: ring contraction vs alpha-oxidation. Ferraz H, et al.

J. Braz. Chem. Soc. 12(5) , 680-684, (2001)

Substituted Derivatives of 3a, 4, 5, 6-Tetrahydrosuccinimido [3, 4-b] Acenaphthen-10-one. Campaigne E and Weddleton RF.

Proc. Indian Acad. Sci. A 95 , (2013)

13H-benzo [6-7] indolo [3, 2-c] quinolines (B [6, 7] IQ): optimization of their DNA triplex-specific stabilization properties. Schmitt P, et al.

Chem. Commun. (Camb.) 9 , 763-764, (2000)

EINECS 229-916-0

3,4-dihydro-7-methoxynaphthalen-1(2H)-one

7-Methoxy-3,4-dihydronaphthalen-1(2H)-one

1(2H)-Naphthalenone, 3,4-dihydro-7-methoxy-

MFCD00001696

7-Methoxy-3,4-dihydro-1(2H)-naphthalenone

7-methoxy-3,4-dihydro-2H-naphthalen-1-one

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 7-Methoxy-1-tetralone
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 7-Methoxy-1-tetralone
Price: ￥278.0/25g ￥88.0/5g
Purity: 97.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

Huangshi Healthday Pharmaceutical Technology Co., Ltd.
China
Product Name: 7-Methoxy-1-tetralone
Price:
Purity: 98.0%
Delivery: 10 Day
Contact: Li
Email: sales@healthdaychem.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7-Methoxy-1-tetralone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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