MRS2698

Modify Date: 2024-01-29 10:33:54

MRS2698 structure	Common Name	MRS2698
	CAS Number	934014-05-8	Molecular Weight	499.22
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉H₁₆N₃O₁₃P₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MRS2698

MRS2698 is a potent and highly selective P2Y2 receptor agonist with an EC50 of 8 nM. MRS2698 is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 receptors[1][2].

Name	MRS2698

Description	MRS2698 is a potent and highly selective P2Y2 receptor agonist with an EC50 of 8 nM. MRS2698 is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 receptors[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	EC50: 8 nM (P2Y2 receptor), 2400 nM (P2Y4 receptor)[1]
In Vitro	MRS2698 is the 2′-amino-2-thio derivative of UTP and is one of the most potent and selective P2Y2R agonist. MRS2698 is 6-fold more potent than the endogenous agonist UTP[1][2].
References	[1]. Ivanov AA, et al. Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. J Med Chem. 2007 Mar 22;50(6):1166-76. [2]. Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther. 2018 Oct;190:24-80.

Molecular Formula	C₉H₁₆N₃O₁₃P₃S
Molecular Weight	499.22

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