MRS2698

Names

[ CAS No. ]:
934014-05-8

[ Name ]:
MRS2698

Biological Activity

[Description]:

MRS2698 is a potent and highly selective P2Y2 receptor agonist with an EC50 of 8 nM. MRS2698 is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 receptors[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[Target]

EC50: 8 nM (P2Y2 receptor), 2400 nM (P2Y4 receptor)[1]


[In Vitro]

MRS2698 is the 2′-amino-2-thio derivative of UTP and is one of the most potent and selective P2Y2R agonist. MRS2698 is 6-fold more potent than the endogenous agonist UTP[1][2].

[References]

[1]. Ivanov AA, et al. Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. J Med Chem. 2007 Mar 22;50(6):1166-76.

[2]. Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther. 2018 Oct;190:24-80.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H16N3O13P3S

[ Molecular Weight ]:
499.22

Related Compounds