Flutropium bromide (Ba 598Br) is a organic bromide salt of flutropium. Flutropium bromide shows an anticholinergic effect. Flutropium bromide effectively suppresses spasms and it can be used for the research of asthma and chronic obstructive pulmonary disease[1][2][3].
Fmoc-D-Glu-ODmab is a glutamic acid derivative[1].
(Ser(Ac)3)-Ghrelin (mouse, rat) is a biologically active peptide.
Procion Blue HB (Reactive Blue 2) is a purinergic antagonist.
Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+[1].
Z-D-Ser(TBu)-OH is a serine derivative[1].
Fmoc-HoPhe-OH is a phenylalanine derivative[1].
Curdione, one of the major sesquiterpene compounds from Rhizoma Curcumae, has been shown to exhibit multiple bioactive properties.IC50 value: 60–80 μMTarget:In vitro: The study of the influence of curdione on the hemorheological changes in blood stasis model rats and thrombolysis in vitro showed that curdione only possessed thrombolytic effect in dose of 0.235 g·L-1 and 2.35 g·L-1, but has not the notable activity of thrombolysis [1]. The effects of curdione on human platelet aggregation induced by thrombin (0.3 U/ml) were tested in vitro. Curdione preferentially inhibited PAF- and thrombin- induced platelet aggregation in a concentration-dependent manner (IC50: 60–80 μM), whereas much higher concentrations of curdione were required to inhibit platelet aggregation induced by ADP and AA. Curdione also inhibited P-selectin expression in PAF-activated platelets. Moreover, curdione caused an increase in cAMP levels and attenuated intracellular Ca2+ mobilization in PAF-activated platelets. In vivo: Curdione showed significant antithrombotic activity [2].
5,8-Dihydroxy-6,7-dimethoxyflavone, isolated from aerial parts of Gnaphalium gaudichaudianum, has antitumor activity[1].
Calycanthoside is a natural compound isolated from Angelica tenuissima[1].
1-Furfurylpyrrole has been identified as a potential contributor of flavor and aroma to popcorn.
10-Hydroxyscandine is an alkaloid from Melodinus tenuicaudatus. 10-Hydroxyscandine can be used for the research of hernia, dyspepsia, abdominal pain, and rheumatic heart[1][2].
(−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats[1][2].
Polyporoid C is a ergostane-type ecdysteroid that exhibits potent anti-inflammatory activity in vivo[1].
WAY-660222 is an active molecule.
A802715 is a methylxanthine derivative. A802715 has a TD50 (toxic dose of 50%) of 0.9-1.1 mM.
Kuwanon B is a flavone derivative that can be found in the root bark of the cultivated mulberry tree (a variety of Morus alba L.)[1].
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis of liposomes.
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
C20:1 Ceramide-d7 is deuterium labeled C20:1 Ceramide.
Dehydrocholic sodium is a hydrocholeretic, increasing bile output to clear increased bile acid load.
O-Phospho-DL-threonine is a threonine derivative[1].
Bis-Tris-d19 is the deuterium labeled Bis-Tris[1]. Bis-Tris is a commonly used buffer[2].
Tenatumomab (ST2146) is a murine monoclonal antibody against tenascin-C. And tenascin-C, the large extracellular glycoprotein, is overexpressed in cancer. Tenatumomab has been used for Pretargeted Antibody Guided Radioimmunotherapy (PAGRIT), and delivering radionuclides to tumors via PAGRIT and direct 131Iodine labeling approach[1][2].
SN-38 glucuronide is an inactive metabolite of the cancer drug Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer[1].
Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive and hypnotic effects.
Vasicine (peganine) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity[1].
Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside, obtained from D-ribose, is also an intermediate for the synthesis of riboside-containing arsenic compound[1].
Etozolin (W-2900A) is a diuretic agent. Etozolin inhibits fluid and electrolyte reabsorption in the loop of Henle. Etozolin can be used in research of congestive heart failure, hypertension and edema[1].
2,3-Dihydro-12,13-dihydroxyeuparin, isolated from Pappobolus species, is a natural product[1].