CLR1501

Modify Date: 2024-01-31 18:38:54

CLR1501 Structure
CLR1501 structure
Common Name CLR1501
CAS Number 1250963-36-0 Molecular Weight 701.674
Density N/A Boiling Point N/A
Molecular Formula C38H59BF2N3O4P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CLR1501


CLR1501, a fluorescently labeled CLR1404 analog, is a cancer cell-selective fluorescence compound[1][2].

 Names

Name Difluoro[2-({hydroxy[(18-{4-[(1H-pyrrol-2-yl-κN)(2H-pyrrol-2-ylidene-κN)methyl]phenyl}octadecyl)oxy]phosphoryl}oxy)-N,N,N-trimethylethanaminiumato(2-)]boron
Synonym More Synonyms

 CLR1501 Biological Activity

Description CLR1501, a fluorescently labeled CLR1404 analog, is a cancer cell-selective fluorescence compound[1][2].
Related Catalog
In Vitro CLR1501 exhibits five- to ninefold preferential uptake in these cancer cell lines in vitro compared to normal fibroblasts[1]. Excitation/emission peaks are 500/517 nm for CLR1501. CLR1501 exhibits tumor selectivity in vitro and in vivo for human glioblastoma stem-like (GSC) cell lines and xenografts[2].
References

[1]. Weichert JP, et al. Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy. Sci Transl Med. 2014 Jun 11;6(240):240ra75.

[2]. Swanson KI, et al. Fluorescent cancer-selective alkylphosphocholine analogs for intraoperative glioma detection. Neurosurgery. 2015 Feb;76(2):115-23; discussion 123-4.

 Chemical & Physical Properties

Molecular Formula C38H59BF2N3O4P
Molecular Weight 701.674
Exact Mass 701.430420

 Synonyms

Boron(1+), difluoro[2-[[hydroxy[[18-[4-[(1H-pyrrol-2-yl-κN)(2H-pyrrol-2-ylidene-κN)methyl]phenyl]octadecyl]oxy]phosphinyl]oxy]-N,N,N-trimethylethanaminiumato, inner salt]-, inner salt
Difluoro[2-({hydroxy[(18-{4-[(1H-pyrrol-2-yl-κN)(2H-pyrrol-2-ylidene-κN)methyl]phenyl}octadecyl)oxy]phosphoryl}oxy)-N,N,N-trimethylethanaminiumato(2-)]boron
CLR1501
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