1250963-36-0

1250963-36-0 structure

Name: CLR1501
Chemical Name: Difluoro[2-({hydroxy[(18-{4-[(1H-pyrrol-2-yl-κN)(2H-pyrrol-2-ylidene-κN)methyl]phenyl}octadecyl)oxy]phosphoryl}oxy)-N,N,N-trimethylethanaminiumato(2-)]boron
CAS Number: 1250963-36-0
Molecular Formula: C₃₈H₅₉BF₂N₃O₄P
Molecular Weight: 701.674
Catalog: Research Areas Cancer
Create Date: 2018-06-09 12:19:55
Modify Date: 2024-01-31 18:38:54
CLR1501, a fluorescently labeled CLR1404 analog, is a cancer cell-selective fluorescence compound[1][2].

Name	Difluoro[2-({hydroxy[(18-{4-[(1H-pyrrol-2-yl-κN)(2H-pyrrol-2-ylidene-κN)methyl]phenyl}octadecyl)oxy]phosphoryl}oxy)-N,N,N-trimethylethanaminiumato(2-)]boron
Synonyms	Boron(1+), difluoro[2-[[hydroxy[[18-[4-[(1H-pyrrol-2-yl-κN)(2H-pyrrol-2-ylidene-κN)methyl]phenyl]octadecyl]oxy]phosphinyl]oxy]-N,N,N-trimethylethanaminiumato, inner salt]-, inner salt Difluoro[2-({hydroxy[(18-{4-[(1H-pyrrol-2-yl-κN)(2H-pyrrol-2-ylidene-κN)methyl]phenyl}octadecyl)oxy]phosphoryl}oxy)-N,N,N-trimethylethanaminiumato(2-)]boron CLR1501

Description	CLR1501, a fluorescently labeled CLR1404 analog, is a cancer cell-selective fluorescence compound[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	CLR1501 exhibits five- to ninefold preferential uptake in these cancer cell lines in vitro compared to normal fibroblasts[1]. Excitation/emission peaks are 500/517 nm for CLR1501. CLR1501 exhibits tumor selectivity in vitro and in vivo for human glioblastoma stem-like (GSC) cell lines and xenografts[2].
References	[1]. Weichert JP, et al. Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy. Sci Transl Med. 2014 Jun 11;6(240):240ra75. [2]. Swanson KI, et al. Fluorescent cancer-selective alkylphosphocholine analogs for intraoperative glioma detection. Neurosurgery. 2015 Feb;76(2):115-23; discussion 123-4.