Chemsrc provides Others's classification, including all related biologically active compounds cover the research fields of cancer, neuroscience, immunology and other popular diseases, etc.


Anti-infection >
Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HIV HSV Influenza Virus Parasite Reverse Transcriptase RSV SARS-CoV
Antibody-drug Conjugate >
ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC-linker Conjugate for PAC
Apoptosis >
Apoptosis Bcl-2 Family c-Myc Caspase DAPK Ferroptosis IAP MDM-2/p53 PKD RIP kinase Survivin Thymidylate Synthase TNF Receptor
Autophagy >
Autophagy LRRK2 ULK Mitophagy
Cell Cycle/DNA Damage >
Antifolate APC ATM/ATR Aurora Kinase Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA-PK DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) G-quadruplex Haspin Kinase HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 ROCK Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeleton >
Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK
Epigenetics >
AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MicroRNA PARP PKC Sirtuin Protein Arginine Deiminase
GPCR/G Protein >
5-HT Receptor Adenosine Receptor Adenylate Cyclase Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR Dopamine Receptor EBI2/GPR183 Endothelin Receptor GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR MCHR1 (GPR24) Melatonin Receptor mGluR Motilin Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor Prostaglandin Receptor Protease-Activated Receptor (PAR) Ras RGS Protein Sigma Receptor Somatostatin Receptor TSH Receptor Urotensin Receptor Vasopressin Receptor Melanocortin Receptor
Immunology/Inflammation >
Aryl Hydrocarbon Receptor CCR Complement System COX CXCR FLAP Histamine Receptor IFNAR Interleukin Related IRAK MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase Salt-inducible Kinase (SIK) SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) Arginase
JAK/STAT Signaling >
EGFR JAK Pim STAT
MAPK/ERK Pathway >
ERK JNK KLF MAP3K MAP4K MAPKAPK2 (MK2) MEK Mixed Lineage Kinase MNK p38 MAPK Raf Ribosomal S6 Kinase (RSK)
Membrane Transporter/Ion Channel >
ATP Synthase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT2 GABA Receptor GlyT HCN Channel iGluR Monoamine Transporter Monocarboxylate Transporter Na+/Ca2+ Exchanger Na+/HCO3- Cotransporter Na+/K+ ATPase nAChR NKCC P-glycoprotein P2X Receptor Potassium Channel Proton Pump SGLT Sodium Channel TRP Channel URAT1
Metabolic Enzyme/Protease >
15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
Casein Kinase ERK Gli GSK-3 Hedgehog Hippo (MST) JAK Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo STAT TGF-beta/Smad Wnt YAP β-catenin γ-secretase
TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
Androgen Receptor Aromatase Estrogen Receptor/ERR Progesterone Receptor Thyroid Hormone Receptor Others

calystegine A3

Calystegine A3 is a natural product that can be isolated from Calystegia sepium[1].

  • CAS Number: 131580-36-4
  • MF: C7H13NO3
  • MW: 159.18300
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Syringetin 3-O-glucoside

Syringetin-3-O-glucosid (Syringetin 3-O-β-D-glucoside), a flavonol glycoside, shows relatively weak DPPH and ABTS radical scavenging activity[1].

  • CAS Number: 40039-49-4
  • MF: C23H24O13
  • MW: 508.42900
  • Catalog: Neurological Disease
  • Density: 1.73g/cm3
  • Boiling Point: 850.6ºC at 760 mmHg
  • Melting Point: 250ºC (dec.)
  • Flash Point: 292.9ºC

18-Azido-stearic acid

18-Azido-stearic acid is a click chemistry reagent containing an azide group. 18-Azido-stearic acid can be used as a hydrophobic bioconjugation linker (using N-Myristoyltransferase) that can be further modified at the azido-position using Click-chemistry[1].

  • CAS Number: 1529763-58-3
  • MF: C18H35N3O2
  • MW: 325.49
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(R)-5-(((2R,3R,5R,6S)-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexan-2-one

Ascr#2 is an ascaroside isolated from Caenorhabditis elegans, potently promotes dauer formation, and also acts as a potent male attractant combined with ascr#3 at low concentration[1].

  • CAS Number: 946524-24-9
  • MF: C12H22O5
  • MW: 246.30000
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Z-Glu-OtBu

Z-Glu-OtBu is a glutamic acid derivative[1].

  • CAS Number: 5891-45-2
  • MF: C17H23NO6
  • MW: 337.368
  • Catalog: Others
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 522.6±50.0 °C at 760 mmHg
  • Melting Point: 83 °C
  • Flash Point: 269.9±30.1 °C

L-Serine isopropyl ester hydrochloride

L-Serine isopropyl ester hydrochloride is a serine derivative[1].

  • CAS Number: 37592-53-3
  • MF: C6H14ClNO3
  • MW: 183.63
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

2,2'-Azobis(2-methylpropionamidine) dihydrochloride

AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1].

  • CAS Number: 2997-92-4
  • MF: C8H20Cl2N6
  • MW: 271.191
  • Catalog: Inflammation/Immunology
  • Density: 0.42
  • Boiling Point: 267ºC at 760 mmHg
  • Melting Point: 160-169 ºC
  • Flash Point: 115.3ºC

11(α)-hydroxyNepasaikosaponin k

11(α)-Hydroxynepasaikosaponin k (compound HOSSc) is a saikosaponin that can be found in B. scorzonerifolium Willd[1].

  • CAS Number: 1152168-63-2
  • MF: C48H80O19
  • MW: 961.14
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LOXO-292

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].

  • CAS Number: 2222755-14-6
  • MF: C29H31N9O3
  • MW: 553.61
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Griffonilide

Griffonilide is a butenolide, isolated from the roots of Semiaquilegia adoxoides, and often occurs alongside lithospermoside[1][2].

  • CAS Number: 61371-55-9
  • MF: C8H8O4
  • MW: 168.147
  • Catalog: Others
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 491.2±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 212.4±22.2 °C

Boc-Phe(2-Me)-OH

(S)-2-((tert-butoxycarbonyl)amino)-3-(o-tolyl)propanoic acid is a phenylalanine derivative[1].

  • CAS Number: 114873-05-1
  • MF: C15H21NO4
  • MW: 279.332
  • Catalog: Others
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 442.5±40.0 °C at 760 mmHg
  • Melting Point: 113ºC
  • Flash Point: 221.4±27.3 °C

Isocupressic acid

Isocupressic acid ((+)-Isocupressic acid) is an abortifacient compound[1].

  • CAS Number: 1909-91-7
  • MF: C20H32O3
  • MW: 320.466
  • Catalog: Others
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 454.2±38.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 242.6±23.3 °C

​Menthyl acetate

​Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. ​Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation[1].

  • CAS Number: 2623-23-6
  • MF: C12H22O2
  • MW: 198.302
  • Catalog: Others
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 229.1±8.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 92.2±0.0 °C

FMOC-3-L-ALA(2-THIENYL)-OH

Fmoc-3-Ala(2-thienyl)-OH is an alanine derivative[1].

  • CAS Number: 130309-35-2
  • MF: C22H19NO4S
  • MW: 393.456
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 617.3±55.0 °C at 760 mmHg
  • Melting Point: 218.5 °C
  • Flash Point: 327.1±31.5 °C

Boc-L-homoserine

Boc-L-Homoserine is a serine derivative[1].

  • CAS Number: 41088-86-2
  • MF: C9H17NO5
  • MW: 219.235
  • Catalog: Others
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 421.6±40.0 °C at 760 mmHg
  • Melting Point: 140°C(lit.)
  • Flash Point: 208.8±27.3 °C

glycylprolyl-4-methylcoumaryl-7-amide

Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)

  • CAS Number: 67341-40-6
  • MF: C17H19N3O4
  • MW: 329.35
  • Catalog: Others
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 369.0±42.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 180.0±29.4 °C

Proprotogracillin

Proprotogracillin is a steroidal glycoside isolated from the bulbs of lilium speciosum[1].

  • CAS Number: 78229-03-5
  • MF: C45H72O17
  • MW: 885.04
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ML-243

ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP[1].

  • CAS Number: 1426576-80-8
  • MF: C14H16N2OS
  • MW: 260.355
  • Catalog: Cancer
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

4-Nitro-L-phenylalanine monohydrate

(S)-2-Amino-3-(4-nitrophenyl)propanoic acid hydrate is a phenylalanine derivative[1].

  • CAS Number: 207591-86-4
  • MF: C9H12N2O5
  • MW: 228.202
  • Catalog: Others
  • Density: 1.408 g/cm3
  • Boiling Point: 495.6ºC at 760 mmHg
  • Melting Point: 245-251 °C (dec.)(lit.)
  • Flash Point: 253.5ºC

MeOSuc-AAPV-AFC

MeOSuc-AAPV-AFC is a biological active peptide. (A highly specific neutrophil elastase substrate, Abs/Em=380/500 nm.)

  • CAS Number: 125791-90-4
  • MF: C31H38F3N5O9
  • MW: 681.66
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Volixibat

Volixibat (SHP626) is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. Volixibat has potential for treatment for non-alcoholic steatohepatitis (NASH)[1][2].

  • CAS Number: 1025216-57-2
  • MF: C38H51N3O12S2
  • MW: 805.954
  • Catalog: Metabolic Disease
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Umirolimus

Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used drug-eluting stent (DES) applications[1].

  • CAS Number: 851536-75-9
  • MF: C55H87NO14
  • MW: 986.278
  • Catalog: Inflammation/Immunology
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 991.0±75.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 553.1±37.1 °C

olivil

Olivil ((-)-Olivile) is a lignan that has weak DPPH radical-scavenging activity (EC50: 176 μM)[1].

  • CAS Number: 2955-23-9
  • MF: C20H24O7
  • MW: 376.400
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 619.3±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 328.3±31.5 °C

Boc-Gln-Gly-Arg-AMC

Boc-Gln-Gly-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1].

  • CAS Number: 113865-85-3
  • MF: C28H40N8O8
  • MW: 616.67
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Etidronic acid

Etidronic acid is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.Target: OthersEtidronic Acid is a chelating agent and may be added to bind to or counter the effects of substances such as arsenic, iron, or other metal ions that can occur in the presence of some soaps. Etidronic acid also acts to retard oxidation of fatty acids. For clarification, a chelator, or chelating agent is a binding component added to many cosmetics, beauty products, and water softeners to form multiple bonds with a single metal ion and neutralize it.

  • CAS Number: 2809-21-4
  • MF: C2H8O7P2
  • MW: 206.028
  • Catalog: Others
  • Density: 2.1±0.1 g/cm3
  • Boiling Point: 578.8±60.0 °C at 760 mmHg
  • Melting Point: 198~199℃
  • Flash Point: 303.8±32.9 °C

deoxynyboquinone

Deoxynyboquinone (NSC 165572;DNQ) is a potent inducer of cancer cell death that induces death of cancer cells in culture with IC50 of 16-210 nM, a substrate for NAD(P)H:quinone oxidoreductase (NQO1); it's lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates extensive reactive oxygen species (ROS).

  • CAS Number: 96748-86-6
  • MF: C15H12N2O4
  • MW: 284.267
  • Catalog: Cancer
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 591.2±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 311.4±30.1 °C

leupeptin

Leupeptin Ac-LL is a protease inhibitor from actinomycetes. Leupeptin Ac-LL has antiplasmin activity[1].

  • CAS Number: 24365-47-7
  • MF: C20H38N6O4
  • MW: 426.55400
  • Catalog: Cancer
  • Density: 1.21g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

H-Glu[cyclo(-Arg-Gly-Asp-D-Phe-Lys)]-cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt

E(c(RGDfK))??is an αvβ3 integrin-specific binding moiety with tumor targeting properties. Increased uptake of E(c(RGDfK))??in human ovarian cancer OVCAR-3 xenograft tumors may be useful in cancer research[1].

  • CAS Number: 250612-47-6
  • MF: C59H87N19O16
  • MW: 1318.46
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

H-Val-Phe-OH

L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has been reported as biocompatible polymer.

  • CAS Number: 3918-92-1
  • MF: C14H20N2O3
  • MW: 264.32000
  • Catalog: Inflammation/Immunology
  • Density: 1.166g/cm3
  • Boiling Point: 493.2ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 252.1ºC

(S)-ATPO

(S)-ATPO is the (S)-enantiomer of ATPO, which is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors[1].

  • CAS Number: 252930-37-3
  • MF: C11H19N2O7P
  • MW: 322.25
  • Catalog: Neurological Disease
  • Density: N/A
  • Boiling Point: 569.2±60.0 °C
  • Melting Point: N/A
  • Flash Point: N/A