2,2'-Azobis(2-methylpropionamidine) dihydrochloride

Modify Date: 2025-08-24 11:20:39

2,2'-Azobis(2-methylpropionamidine) dihydrochloride structure	Common Name	2,2'-Azobis(2-methylpropionamidine) dihydrochloride
	CAS Number	2997-92-4	Molecular Weight	271.191
	Density	0.42	Boiling Point	267ºC at 760 mmHg
	Molecular Formula	C₈H₂₀Cl₂N₆	Melting Point	160-169 ºC
	MSDS	Chinese USA	Flash Point	115.3ºC
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of 2,2'-Azobis(2-methylpropionamidine) dihydrochloride

AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1].

Name	2,2'-Azobis(2-methylpropionamidine) dihydrochloride
Synonym	More Synonyms

Description	AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Sean M. Culbertson, et al. Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins. J. Am. Chem. Soc. 2000, 122, 17, 4032–4038. [2]. Liao W, et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54.

Description

AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1].

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

References

[1]. Sean M. Culbertson, et al. Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins. J. Am. Chem. Soc. 2000, 122, 17, 4032–4038.

[2]. Liao W, et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54.

Density	0.42
Boiling Point	267ºC at 760 mmHg
Melting Point	160-169 ºC
Molecular Formula	C₈H₂₀Cl₂N₆
Molecular Weight	271.191
Flash Point	115.3ºC
Exact Mass	270.112640
PSA	124.46000
LogP	4.07180
Vapour Pressure	8.02E-05mmHg at 25°C
Stability	Unstable. Sensitive to heat and light. Incompatible with strong oxidizing agents, strong acids.
Water Solubility	acetone, dioxane, methanol, ethanol, DMSO and water: soluble

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE4575500

CHEMICAL NAME :: Propionamidine, 2,2'-azobis(2-methyl-, dihydrochloride

CAS REGISTRY NUMBER :: 2997-92-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H18-N6.2Cl-H

MOLECULAR WEIGHT :: 271.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H242-H302-H317
Precautionary Statements	P280
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R43
Safety Phrases	S24-S37
RIDADR	UN 3226 4.1
WGK Germany	1
RTECS	UE4575500
Packaging Group	III
Hazard Class	5.1

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2,2-AZOBIS-(2-AMIDINOPROPANE) HCL

AAPH

Azostarter V 50

ms1

ABAP

2,2-Azobis(2-Methylpropionamidine) Dihydrochloride

ms1(catalyst)

v50

2,2'-Azobis(2

2,2′-azobis(isobutyramidine) dihydrochloride

Propanimidamide, 2,2'-[(E)-1,2-diazenediyl]bis[2-methyl-, hydrochloride (1:2)

2,2‘-Azobis(2-methylpropionamidine) dihydrochloride

2,2'-azobis(2-methyl-2-propionamidine) dihydrochloride

2,2'-azobisi(2-amidinopropane) hydrochloride

2,2'-Azobis(2-methylpropionamidine) Dihydrochloride

2,2'-(Diazene-1,2-diyl)bis(2-methylpropanimidamide) dihydrochloride

2,2'-(e)-diazene-1,2-diylbis(2-methylpropanimidamide) dihydrochloride

EINECS 221-070-0

2,2’-Azodiisobutyramidine Dihydrochloride

MFCD00142725

2,2'-[(E)-1,2-Diazenediyl]bis(2-methylpropanimidamide) dihydrochloride

2,2'-Azobis-amidinopropane

AIBA

2,2'-(3-NITROPHENYLIMINO)-DIETHANOL

2,2'-Azobis(isobutyramidine) 2HCl

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2,2'-Azobis(2-methylpropionamidine) dihydrochloride
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2,2'-Azobis(2-methylpropionamidine) dihydrochloride
Price: ￥168.0/100g ￥98.0/25g ￥548.0/500g
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,2'-Azobis(2-methylpropionamidine) dihydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2,2'-Azobis(2-methylpropionamidine) dihydrochloride
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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Price: ￥37/10g

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2,2'-Azobis(2-methylpropionamidine) dihydrochloride

Use of 2,2'-Azobis(2-methylpropionamidine) dihydrochloride

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MSDS

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