2,2'-Azobis(2-methylpropionamidine) dihydrochloride

Names

[ Name ]:
2,2'-Azobis(2-methylpropionamidine) dihydrochloride

[Synonym ]:
2,2-AZOBIS-(2-AMIDINOPROPANE) HCL
AAPH
Azostarter V 50
ms1
ABAP
2,2-Azobis(2-Methylpropionamidine) Dihydrochloride
ms1(catalyst)
v50
2,2'-Azobis(2
2,2′-azobis(isobutyramidine) dihydrochloride
Propanimidamide, 2,2'-[(E)-1,2-diazenediyl]bis[2-methyl-, hydrochloride (1:2)
2,2‘-Azobis(2-methylpropionamidine) dihydrochloride
2,2'-azobis(2-methyl-2-propionamidine) dihydrochloride
2,2'-azobisi(2-amidinopropane) hydrochloride
2,2'-Azobis(2-methylpropionamidine) Dihydrochloride
2,2'-(Diazene-1,2-diyl)bis(2-methylpropanimidamide) dihydrochloride
2,2'-(e)-diazene-1,2-diylbis(2-methylpropanimidamide) dihydrochloride
EINECS 221-070-0
2,2’-Azodiisobutyramidine Dihydrochloride
MFCD00142725
2,2'-[(E)-1,2-Diazenediyl]bis(2-methylpropanimidamide) dihydrochloride
2,2'-Azobis-amidinopropane
AIBA
2,2'-(3-NITROPHENYLIMINO)-DIETHANOL
2,2'-Azobis(isobutyramidine) 2HCl

Biological Activity

[Description]:

AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Sean M. Culbertson, et al. Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins. J. Am. Chem. Soc. 2000, 122, 17, 4032–4038.

[2]. Liao W, et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54.

Chemical & Physical Properties

[ Density]:
0.42

[ Boiling Point ]:
267ºC at 760 mmHg

[ Melting Point ]:
160-169 ºC

[ Molecular Formula ]:
C₈H₂₀Cl₂N₆

[ Molecular Weight ]:
271.191

[ Flash Point ]:
115.3ºC

[ Exact Mass ]:
270.112640

[ PSA ]:
124.46000

[ LogP ]:
4.07180

[ Vapour Pressure ]:
8.02E-05mmHg at 25°C

[ Stability ]:
Unstable. Sensitive to heat and light. Incompatible with strong oxidizing agents, strong acids.

[ Water Solubility ]:
acetone, dioxane, methanol, ethanol, DMSO and water: soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE4575500

CHEMICAL NAME :: Propionamidine, 2,2'-azobis(2-methyl-, dihydrochloride

CAS REGISTRY NUMBER :: 2997-92-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H18-N6.2Cl-H

MOLECULAR WEIGHT :: 271.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H242-H302-H317

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R43

[ Safety Phrases ]:
S24-S37

[ RIDADR ]:
UN 3226 4.1

[ WGK Germany ]:
1

[ RTECS ]:
UE4575500

[ Packaging Group ]:
III

[ Hazard Class ]:
5.1

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Related Compounds

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