Etidronic acid

Modify Date: 2024-01-02 10:08:27

Etidronic acid structure	Common Name	Etidronic acid
	CAS Number	2809-21-4	Molecular Weight	206.028
	Density	2.1±0.1 g/cm3	Boiling Point	578.8±60.0 °C at 760 mmHg
	Molecular Formula	C₂H₈O₇P₂	Melting Point	198~199℃
	MSDS	Chinese USA	Flash Point	303.8±32.9 °C
	Symbol	GHS05	Signal Word	Danger

Use of Etidronic acid

Etidronic acid is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.Target: OthersEtidronic Acid is a chelating agent and may be added to bind to or counter the effects of substances such as arsenic, iron, or other metal ions that can occur in the presence of some soaps. Etidronic acid also acts to retard oxidation of fatty acids. For clarification, a chelator, or chelating agent is a binding component added to many cosmetics, beauty products, and water softeners to form multiple bonds with a single metal ion and neutralize it.

Name	etidronic acid
Synonym	More Synonyms

Description	Etidronic acid is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.Target: OthersEtidronic Acid is a chelating agent and may be added to bind to or counter the effects of substances such as arsenic, iron, or other metal ions that can occur in the presence of some soaps. Etidronic acid also acts to retard oxidation of fatty acids. For clarification, a chelator, or chelating agent is a binding component added to many cosmetics, beauty products, and water softeners to form multiple bonds with a single metal ion and neutralize it.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. http://www.truthinaging.com/ingredients/etidronic-acid

Density	2.1±0.1 g/cm3
Boiling Point	578.8±60.0 °C at 760 mmHg
Melting Point	198~199℃
Molecular Formula	C₂H₈O₇P₂
Molecular Weight	206.028
Flash Point	303.8±32.9 °C
Exact Mass	205.974518
PSA	154.91000
LogP	-3.54
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.586
Stability	Stable. Incompatible with strong oxidizing agents.

Etidronic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ8562100

CHEMICAL NAME :: Phosphonic acid, (1-hydroxyethylidene)di-

CAS REGISTRY NUMBER :: 2809-21-4

BEILSTEIN REFERENCE NO. :: 1789291

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C2-H8-O7-P2

MOLECULAR WEIGHT :: 206.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 50,879,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)

REFERENCE :: JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 20,91,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 19,87,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 49,837,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),16A,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1400 mg/kg

SEX/DURATION :: female 11-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 22,47,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0985 No. of Facilities: 404 (estimated) No. of Industries: 10 No. of Occupations: 7 No. of Employees: 6655 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0985 No. of Facilities: 3273 (estimated) No. of Industries: 73 No. of Occupations: 46 No. of Employees: 44885 (estimated) No. of Female Employees: 3814 (estimated)

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H290-H318
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi
Risk Phrases	37/38-41
Safety Phrases	S26-S39
RIDADR	UN 3265
WGK Germany	2
RTECS	SZ8562100
Packaging Group	II
Hazard Class	8
HS Code	2931900090

Precursor 8
CAS#:75-36-5 Acetyl chloride CAS#:64-19-7 acetic acid CAS#:50-00-0 Formaldehyde CAS#:628-63-7 Pentyl acetate
CAS#:60-35-5 Acetamide CAS#:1655-07-8 Ethyl 2-oxocycl... CAS#:10472-24-9 2-Methoxy carbo... CAS#:140-39-6 P-cresyl acetate
DownStream 2
CAS#:7664-38-2 Phosphoric acid CAS#:64-19-7 acetic acid

HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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Drug Discov. Today 16 , 697-703, (2011)

Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effec...

(1-Hydroxyethane-1,1-diyl)diphosphonic acid

Etidronsaeure

Acetodiphosphonic acid

ethane-1-hydroxy-1,1-diphosphonic acid

MFCD00070585

1-hydroxyethane 1,1-diphosphonic acid

Hydroxyethanediphosphonic acid

EHDP

Phosphonic acid, (1-hydroxyethylidene)bis-

Osteoscan

(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)

1-Hydroxyethylidenediphosphonic acid

1-Hydroxyethylidene-1,1-diphosphonic Acid

(1-hydroxy-1-phosphonoethyl)phosphonic acid

Didronel IV

ethane-1-hydroxy-1,1-bisphosphonic acid

acide etidronique

EINECS 220-552-8

Oxyethylidenediphosphonic acid

HEDP

1-Hydroxyeth

Etidronic acid monohydrate (HEDP)

DEQUEST 2010

Turpinal SL

Etidronic acid

(1-Hydroxy-1,1-ethanediyl)bis(phosphonic acid)

acidum etidronicum

Etidronate

1-Hydroxyethane-1,1-diphosphonic acid

acido etidronico

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Etidronic acid
Price: ￥258.0/500g ￥88.0/100g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Etidronic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Hydroxyethane-1,1-diphosphonic Acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: etidronic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Etidronic acid

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