Halo-DBCO is a click chemistry reagent containing dibenzocyclooctyne (DBCO). Halo-DBCO can be used as a ligand to react with HaloTag to form covalent HaloTag ligand couples.
Gp100 (619-627) is amino acids 619 to 627 fragment of human melanoma antigen glycoprotein 100 (gp100). Gp100 has been a widely studied target for melanoma immunotherapy[1].
Ethyl-L-NIO hydrochloride is a potent and competitive human dimethylarginine dimethylaminohydrolase 1 (hDDAH-1) inhibitor with an IC50 of 70 μM and a Ki of 32 μM[1].
Guanidinosuccinic acid is a nitrogenous metabolite isolated in excess from serum and urine.
Ibuproxam (G 277) is a non-steroidal anti-inflammatory agent[1].
Oleanolic acid-3-O-glucosyl(1-2)xylyl(1-3)glucosiduronic acid is a nature occurring triterpene saponin[1].
Cy3 NHS (Cyanine3 NHS ester) is a water-soluble and yellow emitting fluorescent dye for labeling amino-groups in biomolecules. Used to label soluble proteins, peptides, and oligonucleotides/DNA.
PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].
FITC is a derivative of fluorescein for the labeling of amines.
Semastatin-5B is an anti-angiogenic 17-amino acid peptide. Semastatin-5B can be derived from proteins containing type I thrombospondin motifs[1].
Sodium lauryl sulfoacetate is a solid anionic surfactant of vegetable origin[1]. Sodium lauryl sulfoacetate is an immunoadjuvant. Anti-immunosuppressive effect[2].
2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects[1][2].
Thiodicarb is a carbamate insecticide used to control flies in animal and poultry houses and dairies. Thiodicarb is metabolized into methomyl in animals and plants, and subsequently degraded into carbon dioxide and acetonitrile[1].
TNH is a dimer that can enter living cells and recruit proteins into cellular structures[1].
GPR34 receptor antagonist 2 (Compound D2) is a GPR34 receptor antagonist. GPR34 receptor antagonist 2 can be used for immune diseases, inflammatory diseases research[1].
Bisabolol oxide A possesses antihyperalgesic and antiedematous effects with oral activity[1].
H-Met-Arg-OH is a biologically active peptide.
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2].
JNJ-678 (JNJ-53718678) is a novel fusion protein inhibitor in clinical trials for the treatment of respiratory syncytial virus.
Yadanzioside F is one of the toxic components found in Brucea javanica[1]. Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties[2].
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is a disaccharide of xylose monomers with a β-1, 4 bond between monomers[1].
Tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins[1][2].
H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe is a nonimmunosuppressive cyclosporin A derivative. H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe has the potential for the research of congenital muscular dystrophy[1].
HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. HA15 exhibits strong efficacy in melanoma cells. The 50% inhibitory concentration (IC50) in A375 cells was between 1 and 2.5 mM HA15. [1]In vivo: HA15 induces ER stress leading to cancer cell death. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cellseither sensitive or resistant to BRAF inhibitors. [1]
(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes[1].
3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol, a cationic liposome reagent, has been investigated in cancer gene therapy and vaccine delivery system[1].
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) [1][2].
Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves[1][2].
δ-Amyrenone (Delta-Amyrone) is a pentacyclic triterpene compound from S. lineare, with anti-inflammatory effects[1].
(-)-Asarinin is a extract lignan from Zanthoxylum armatum, mainly produced in roots of this herb[1].