934385-55-4

934385-55-4 structure

Name: Cyclic MKEY
Chemical Name: Cyclic MKEY
CAS Number: 934385-55-4
Molecular Formula: C₁₁₃H₁₇₄N₂₈O₃₄S₂
Molecular Weight: 2532.89
Catalog: Research Areas Cancer
Create Date: 2019-09-10 19:47:03
Modify Date: 2025-08-25 20:48:42
Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice[1][2].

Name	Cyclic MKEY

Description	Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	CXCL4-CCL5 heterodimer formation[1]
References	[1]. Fan Y,et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016 Sep 15;5(9). pii: e003615. [2]. Iida Y, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):718-26.

Molecular Formula	C₁₁₃H₁₇₄N₂₈O₃₄S₂
Molecular Weight	2532.89