Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.Target: androgen receptor in vitro: Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM [1]. lutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect [2]. Flutamide provides treatment for prostate cancer when used along with leuprolide [3].in vivo: Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity [4].
4-Isothiocyanatophenyl α-D-Mannopyranoside, an organic isothiocyanate, is a building block and reagent which is used for preparing neoglycoproteins[1].
YIGSR is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells[1].
WAY-351783 is an active molecule.
OG 488, acid, a fluorescent pH indicator, has many applications in biochemistry and neurosciences[1].
Acetamide-2,2,2-d3 is the deuterium labeled Acetamide-2,2,2-d3[1].
(S,S)-Pisatin (compound 8) is a dimeric pterocarpan derivative is isolated from the grains of millettia pachyloba[1][2].
Arundamine is a nature product. Arundamine can be isolated from roots of Arundo donax L[1].
Tyr-Tyr-Tyr-Tyr-Tyr-Tyr is a tyrosine derivative[1].
SALMF amide 2, a neuropeptide S2 from the starfish Asterias rubens, is involved in the regulation of eversion of the cardiac stomach in starfish[1].
Lucifer Yellow CH dilithium salt is a highly fluorescent dye that is useful in marking nerve cells[1]. Lucifer Yellow CH dilithium salt is assumed to be nontoxic, and it is membrane impermeable and highly dissociated at physiological pH values[2][3].
Methyl 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects[1].
IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor (TAFI), with an Ki(app) of 0.14 μM. IQB-782 shows a potent mucolytic-expectorant activity[1][2].
Aristolindiquinone can be isolated from Aristolwhia indica[1].
Hexylene glycol is a small molecular weight surfactant, widely used as an industrial coating solvent, does not cause adverse health or environmental effects.
Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 uM, is the most active compound of this series .
N-lauroylsarcosine (NLS) is an anionic surfactant, and can be used as a permeation enhancer. The mixture of NLS in 25–50% ethanol acts synergistically to increase skin permeability, which may be useful for transdermal drug delivery research[1].
2α,3β,24-Trihydroxyurs-12-en-28-oic acid is a natural product that can be isolated from Salvia palaestina[1].
diSulfo-Cy3 alkyne is a water-soluble dye and a Click Chemistry reagent containing an azide group. Absorbance and emission of the dye are identical to Cy3 fluorophore. diSulfo-Cy3 alkyne can be used for the labeling of proteins, and even intact biological objects in water phase[1].
(1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC50 value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor[1].
Fluorogen binding modulator-1 (PubChem SID 125240934) is a fluorogen activating protein (FAP)-fluorogen binding modulator with -log EC50s of 6.61 and 6.37 for AM2.2-β2AR and AM2.2-GPR32, respectively[1].
Kemptide (amide) is a heptapeptide with properties of a cytophilic substrate. Kemptide is a molecule preserving cell membrane intactness, is phosphorylated by PKI, the inhibitory protein specific for cAMP-dependent protein kinase (PK)[1].
Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a synthetic polypeptide that can serve as a substrate for the protease from Aeribacillus pallidus VP3 (SPVP), the serine alkaline protease from Caldicoprobacter guelmensis (SAPCG) strain D2C22T, the alcalase ultra 2.5 L and the thermolsyin type X[1].
2-Aminoethan-1-ol-13C2 hydrochloride is the 13C labeled 2-Aminoethan-1-ol hydrochloride[1].
N-(4-Fluoro-1,3-benzothiazol-2-yl)-N-methylglycine is a Glycine (HY-Y0966) derivative[1].
Witepsol is a selective lipid-based vehicle for use in drug delivery systems[1].
CAY10731 (compound 3) is a highly selective fluorescent probe for detection of hydrogen sulfide (H2S). CAY10731 is used to monitor exo- and endogenous H2S in both cancer and normal cells. CAY10731 is applied for imaging of H2S in living tissues at variable depths and in nematodes[1].
2-Amino-3-mercaptopropanoic acid is a cysteine derivative[1].
Sulfo-Cyanine5.5 amine, water soluble cyanine dye, consists of four sulfonate groups and has highly hydrophilic. Sulfo-Cyanine5.5 amine is an amine-containing fluorescent dye, the aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc). Sulfo-Cyanine5.5 amine can be used for the research of far red/NIR applications (such as in vivo imaging) and also can be used for enzymatic transamination labeling[1].
Fmoc-Ile-Ser(psi(Me,Me)pro)-OH is a dipeptide.