CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
UG5700000
-
CHEMICAL NAME :
-
m-Propionotoluidide, 2-methyl-4'-nitro-alpha,alpha,alpha-triflouro-
-
CAS REGISTRY NUMBER :
-
13311-84-7
-
LAST UPDATED :
-
199806
-
DATA ITEMS CITED :
-
27
-
MOLECULAR FORMULA :
-
C11-H11-F3-N2-O3
-
MOLECULAR WEIGHT :
-
276.24
-
WISWESSER LINE NOTATION :
-
FXFFR BNW EMVY1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
-
310 mg/kg/31D-I
-
TOXIC EFFECTS :
-
Behavioral - euphoria
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
787 mg/kg
-
TOXIC EFFECTS :
-
Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - incontinence Nutritional and Gross Metabolic - body temperature decrease
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
289 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
>2 gm/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - nausea or vomiting Gastrointestinal - other changes Liver - other changes
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
700 mg/kg/28D-I
-
TOXIC EFFECTS :
-
Endocrine - androgenic Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
27300 mg/kg/52W-I
-
TOXIC EFFECTS :
-
Blood - pigmented or nucleated red blood cells Biochemical - Metabolism (Intermediary) - other proteins Related to Chronic Data - changes in prostate weight
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
2730 mg/kg/1Y-I
-
TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - testicular tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
1050 mg/kg
-
SEX/DURATION :
-
female 14-20 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - urogenital system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
150 mg/kg
-
SEX/DURATION :
-
male 30 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
375 mg/kg
-
SEX/DURATION :
-
male 15 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
3840 mg/kg
-
SEX/DURATION :
-
male 64 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
280 mg/kg
-
SEX/DURATION :
-
male 7 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
525 mg/kg
-
SEX/DURATION :
-
female 14-20 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - urogenital system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
275 mg/kg
-
SEX/DURATION :
-
female 11-21 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - Central Nervous System
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
70 mg/kg
-
SEX/DURATION :
-
male 7 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
400 mg/kg
-
SEX/DURATION :
-
female 16-19 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
DOSE :
-
65 mg/kg
-
SEX/DURATION :
-
female 10-22 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - delayed effects
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
DOSE :
-
29040 ug/kg
-
SEX/DURATION :
-
male 17 week(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Parenteral
-
DOSE :
-
350 mg/kg
-
SEX/DURATION :
-
male 7 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Parenteral
-
DOSE :
-
200 mg/kg
-
SEX/DURATION :
-
female 16-17 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - other effects on male Endocrine - androgenic
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
80 mg/kg
-
SEX/DURATION :
-
male 10 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
400 mg/kg
-
SEX/DURATION :
-
male 10 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
1 gm/kg
-
SEX/DURATION :
-
female 13-18 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - other postnatal measures or effects
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
300 mg/kg
-
SEX/DURATION :
-
female 14-16 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - urogenital system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
1225 mg/kg
-
SEX/DURATION :
-
female 6 week(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - other effects to embryo
MUTATION DATA
-
TYPE OF TEST :
-
DNA inhibition
-
TEST SYSTEM :
-
Rodent - rat Liver
-
DOSE/DURATION :
-
50 umol/L
-
REFERENCE :
-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 13,373,1992
|