(1S,3R)-GNE-502

Modify Date: 2025-09-18 20:32:46

(1S,3R)-GNE-502 Structure
(1S,3R)-GNE-502 structure
 Common Name (1S,3R)-GNE-502
CAS Number 1953134-15-0 Molecular Weight 471.59
Density N/A Boiling Point N/A
Molecular Formula C25H30FN3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (1S,3R)-GNE-502


(1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC50 value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor[1].

 Names

Name (1S,3R)-GNE-502

 (1S,3R)-GNE-502 Biological Activity

Description (1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC50 value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor[1].
Related Catalog
Target

ERα:13 nM (EC50)

References

[1]. Simon Charles Goodacre, et al. Tetrahydro-Pyrido[3,4-b]Indole Estrogen Receptor Modulators And Uses Thereof. WO2016097072A1.

 Chemical & Physical Properties

Molecular Formula C25H30FN3O3S
Molecular Weight 471.59
InChIKey ALLRPIPLWLLBGX-NSYGIPOTSA-N
SMILES CC1Cc2c([nH]c3ccccc23)C(c2ccc(OCCN3CC(CF)C3)cc2)N1S(C)(=O)=O
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