PA22-2 (free acid) (Cys-Laminin A chain 2091-2108) is a peptide that supports neurite outgrowth and stimulates neuronal-like process formation. PA22-2 (free acid) can be used to culture human adenoid cystic carcinoma cells, and in the preparation of peptide-functionalized supported phospholipid bilayers[1][2][3].
2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.
Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2].
IB87 is an amine nicotine hapten. IB87 contains a linker e attached to the 6-position of (S)-enantiomer of nicotine. IB87 conjugates to KLH via carbodiimide-mediated reactions[1].
2-Desoxypleniradin-4-0-a-L-rhamnopyranoside is a flavonoid. 2-Desoxypleniradin-4-0-a-L-rhamnopyranoside can be isolated from Helenium radiatum[1].
ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER)α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness[1].
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1].
Cinnamtannin D2 (compound 13) is a cinnamon tannin isolated from Vaccinium vitis-idaea L[1].
Osteocalcin (7-19) (human) is a peptide fragment of Osteocalcin, can be used as a peptide tag.
Octyl acetate is one of major components of essential oils in the vittae, or oil tubes, of the wild parsnip (Pastinaca sativa). Octyl acetate has antioxidant activity[1].
Angelicide is an active compound. Angelicide can be isolated from the medicinal plant dang-gui (A. sinensis)[1].
(R)-2-Amino-3-cyclohexylpropanoic acid hydrate(1:x) is an alanine derivative[1].
JF669, SE, a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669−HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm)[1].
Foliamenthic acid is a monoterpenoid compound that can be isolated from methanol extracts of the roots and leaves of the foliate[1].
CER5-2’S-d9 is deuterium labeled CER5-2’S.
Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1[1][2].
ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice[1].
Cbz-Valaciclovir (Benzyloxycarbonyl valacyclovir) can be used to prepare Valaciclovir (HY-17425) and for antiviral research[1].
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor)[1][2].
Ralaniten triacetate (EPI-506), the pro-drug of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7[1][2].
Tos-Gly-Pro-Arg-ANBA-IPA (acetate) is a peptide substrate for luminescence measurement. Sequence: Tos-Gly-Pro-Arg-ANBA-IPA.
Farrerol 7-O-β-D-glucopyranoside (Farrerol 7-O-glucoside) is a flavonoid compound isolated from the leaves of Rhododendron dauricum L[1].
Quazomotide is a WT1 class II peptide epitope with sequences of RSDELVRHHNMHQRNMTKL. Quazomotide stimulates a peptide-specific CD4(+) response, to recognize WT1(+) tumor cells. Quazomotide is an immunological agent for active immunization, as well as an antineoplastic agent[1][2].
WST-8 is a water-soluble tetrazolium dye, WST-8 enhances sensitivity of the WST-8-based assay over the conventional MTS-based assay.
IA1-8H2 is a non-covalent, non-competitive inhibitor of PHPT1 (IC50: 3.4 μM). IA1-8H2 can be used for research of lung cancer, hepatocarcinoma, and renal cancer[1].
Sebetralstat is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases[1].
Luteolin-7-O-α-L-arabinopyranosyl (1→6)-β-D-glucopyranoside is a flavonoid with antiradical activity[1].
Mebeverine acid D5 is the deuterium labeled Mebeverine Acid; Mebeverine Acid is a metabolite of Mebeverine, that is an antispasmodic.
DACN(Tos,Suc-OH) is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. DACNs possess high thermal and chemical stability along with comparable click reactivity[1].
n-Butyl-amine-d9 (Hydrochloride) is the deuterium labeled Butylamine hydrochloride[1].