Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent[1]. Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cell[1].
Biotin-Gastrin-1, human (1-17) is a biological active peptide. (Biotin-labeled HY-P1097)
AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties[1].
5’(R)-C-Methyl-5-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1].
Isorauhimbine is an alkaloid, can be isolated from R. serpentina[1].
Isotocin ((Ser4,Ile8)-Oxytocin) is a biologically active peptide.
2'-Deoxyadenosine-13C10,15N5 is 13C and 15N-labeled 2'-Deoxyadenosine (HY-W040329). 2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA.
Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
NVP-CLR457 (compound 40) is an orally active, potent and balanced pan-class I PI3K inhibitor. NVP-CLR457 shows a clear dose-dependent PK/PD/efficacy relationship. NVP-CLR457 has antitumor activity[1].
Acyl Carrier Protein (ACP) (65-74) is an active acyl carrier protein (ACP) fragment[1].
p-Azoxyanisole-d6 is the deuterium labeled p-Azoxyanisole[1].
UCCF-853 is a CFTR modulator[1].
A-443654 is a potent Akt1/2/3 inhbitor, with a Ki of 160 pM for Akt1.
Carpalasionin is a natural product derived from Rabdosia serra. Rabdosia serra is an important component of Chinese herbal teas, traditionally used to treat hepatitis, jaundice, cholecystitis and colitis[1].
GBT 440 (Voxelotor) is an orally bioavailable modulator of sickle cell hemoglobin.
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models[1].
ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
Parvisoflavanone is an isoflavanone that can be isolated from Mucuna pruriens[1].
Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.
Tetramethylammonium perchlorate is used as an intermediate in organic and chemical synthesis. It is used as mobile phase in HPLC analysis and quantification of olanzapine, clozapine and N-desmethylclozapine. It acts as a supporting electrolyte in the electrochemical reduction of 1-bromodecane, 1-iodododecane, 2-iodooctane, and 2-bromooctane on a mercury cathode.
SHP2 IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM.
AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm)[1].
Tetramethyl-ammonium Bromide-d12 is the deuterium labeled TMAB[1].
Tepoditamab (MCLA-117) is a bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab (MCLA-117) kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells and can be used in acute myeloid leukaemia (AML) research[1].
YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis. IC50 value:Target: RNA Helicase AES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 μM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
BCL6-IN-3 (example 20a) is a B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity, extracted from patent WO2018215801A1. BCL6-IN-3 (example 20a) exhibits a GI50 of 70 nM in SU-DHL4 cells[1].
Monoethyl phthalate-d4 is the deuterium labeled Monoethyl phthalate[1]. Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule[2][3].
μ opioid receptor agonist 2 （Compound H-3）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases[1].
Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase[1].