2566-90-7

2566-90-7 structure

Name: Docosahexaenoic Acid methyl ester
Chemical Name: Docosahexaenoic Acid methyl ester
CAS Number: 2566-90-7
Molecular Formula: C₂₃H₃₄O₂
Molecular Weight: 342.515
Catalog: analytical chemistry food safety Fatty acid, fatty acid methyl ester
Create Date: 2019-01-09 23:00:33
Modify Date: 2024-01-02 16:02:26
Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

Name	Docosahexaenoic Acid methyl ester
Synonyms	4,7,10,13,16,19-Docosahexaenoic acid, methyl ester, (all-Z)- fame 22:6n-3 docosa-4c,7c,10c,13c,16c,19c-hexaenoic acid methyl ester all-cis-4,7,10,13,16,19-docosahexaenoic acid methyl ester Methyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate 4,7,10,13,16,19-Docosahexaenoic acid, methyl ester, (4Z,7Z,10Z,13Z,16Z,19Z)- Methyl (4E,7E,10E,13E,16E,19E)-4,7,10,13,16,19-docosahexaenoate Methyl (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahexaenoate DHA methyl ester Docosahexaenoic acid methyl Docosa-4c,7c,10c,13c,16c,19c-hexaensaeure-methylester methyl 4,7,10,13,16,19-docosahexaenoate 4,7,10,13,16,19-Docosahexaenoic acid, methyl ester, (4E,7E,10E,13E,16E,19E)- all-cis-4,7,10,13,16,19-Docosahexaenoic acid methyl ester solution Fame 22:6n-3,Methyl all-cis-4,7,10,13,16,19-docosahexenoate,Methyl DHA

Description	Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Sharp wave (SPW) incidence relative to baseline appears to decrease following Docosahexaenoic Acid methyl ester (DHA-Me) application[1]. There is no generation of a new protein band when bovine serum albumin (BSA) is exposed to the Fe2+ and ascorbic acid (AsA) mixed-function oxidation system in the absence of Docosahexaenoic Acid methyl ester (DHA). However, the high-molecular-weight protein band is observed after only 24 h when BSA is incubated with DHA. Incubation of BSA with 1.0 mM DHA leads to a substantial increase in protein carbonyl content and the addition of oxygen radical scavengers leads to a substantial decrease in protein carbonyl content[2].
Kinase Assay	Protein (1 mg/mL) is incubated with Docosahexaenoic Acid methyl ester (DHA) (1.0 mM) in 50 mM HEPES buffer (pH 7.4) containing 0.2% (w/v) of Tween 20 at 37°C. Mannitol, histidine, sodium benzoate, or KI is added at final concentration of 0.5 M, 0.2 M, 0.5 M, or 0.1 M, respectively. Reactive oxygen species are generated by addition of FeSO4 (1 μM) and ascorbic acid (AsA, 20 μM)[2].
References	[1]. Taha AY, et al. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Res. 2013 Nov 6;1537:9-17. [2]. Liu W, et al. Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products. Biochim Biophys Acta. 2007 Feb;1774(2):258-66.

Density	0.9±0.1 g/cm3
Boiling Point	429.9±24.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₄O₂
Molecular Weight	342.515
Flash Point	103.9±21.2 °C
Exact Mass	342.255890
PSA	26.30000
LogP	7.24
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.505
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes	F,N,Xn
Risk Phrases	11-67-65-50/53-38
Safety Phrases	16-62-61-24/25
RIDADR	UN1170 3/PG 2
WGK Germany	3
Hazard Class	3.0
HS Code	29161900

Precursor 8
67-56-1 31820-15-2 186581-53-3 6217-54-5
928-96-1 84254-20-6 81345-02-0 21676-05-1
DownStream 1
6217-54-5

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