GBT-440

Modify Date: 2025-08-23 09:36:34

GBT-440 Structure
GBT-440 structure
Common Name GBT-440
CAS Number 1446321-46-5 Molecular Weight 337.372
Density 1.2±0.1 g/cm3 Boiling Point 539.2±50.0 °C at 760 mmHg
Molecular Formula C19H19N3O3 Melting Point N/A
MSDS N/A Flash Point 279.9±30.1 °C

 Use of GBT-440


GBT 440 (Voxelotor) is an orally bioavailable modulator of sickle cell hemoglobin.

 Names

Name voxelotor
Synonym More Synonyms

 GBT-440 Biological Activity

Description GBT 440 (Voxelotor) is an orally bioavailable modulator of sickle cell hemoglobin.
Related Catalog
References

[1]. Metcalf B, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 539.2±50.0 °C at 760 mmHg
Molecular Formula C19H19N3O3
Molecular Weight 337.372
Flash Point 279.9±30.1 °C
Exact Mass 337.142639
LogP 2.85
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.617
InChIKey FWCVZAQENIZVMY-UHFFFAOYSA-N
SMILES CC(C)n1nccc1-c1ncccc1COc1cccc(O)c1C=O
Storage condition -20℃

 Synonyms

Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-
2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde
voxelotor
GBT-440
GBT 440
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Price: $110/10mM*1mLinDMSO

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