1119503-63-7
1119503-63-7 structure
- Name: JNc-440
- Chemical Name: N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide
- CAS Number: 1119503-63-7
- Molecular Formula: C26H24N4O3
- Molecular Weight: 440.494
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2020-01-11 20:14:24
- Modify Date: 2025-09-16 03:18:23
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JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3; shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice.
| Name | N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide |
|---|---|
| Synonyms |
2-Quinazolinecarboxamide, N-[3-[(2,2-diphenylacetyl)amino]propyl]-4-hydroxy-
N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide |
| Description | JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3; shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice. |
|---|---|
| References | References 1. He D, et al. EMBO Mol Med. 2017 Sep 12. pii: e201707725. View Related Products by Target TRP Channel |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H24N4O3 |
| Molecular Weight | 440.494 |
| Exact Mass | 440.184845 |
| LogP | 2.23 |
| Index of Refraction | 1.656 |