JNc-440
Modify Date: 2025-09-16 03:18:23
JNc-440 structure
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Common Name | JNc-440 | ||
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| CAS Number | 1119503-63-7 | Molecular Weight | 440.494 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H24N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNc-440JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3; shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice. |
| Name | N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide |
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| Synonym | More Synonyms |
| Description | JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3; shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice. |
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| References | References 1. He D, et al. EMBO Mol Med. 2017 Sep 12. pii: e201707725. View Related Products by Target TRP Channel |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H24N4O3 |
| Molecular Weight | 440.494 |
| Exact Mass | 440.184845 |
| LogP | 2.23 |
| Index of Refraction | 1.656 |
| 2-Quinazolinecarboxamide, N-[3-[(2,2-diphenylacetyl)amino]propyl]-4-hydroxy- |
| N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide |