Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulates mitochondrial ATP synthesis.
(-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (compound 10) is a lignan isolated from Hedyotis uncinella[1].
Polycytidylic acid potassium is an immunostimulant and synthetic double-stranded RNA. Polycytidylic acid potassium can be used experimentally to model viral infections in vivo. Polycytidylic acid potassium is a common tool in immune system research[1].
Biotin-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
Luteinizing hormone (human), a heterodimeric glycoprotein hormone produced by the pituitary gland (LH), plays key roles in human reproduction[1].
SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation[1].
2-Methyl-2’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Qianhucoumarin G is a natural coumarin derivative found in Ligustici Radix[1].
CU CPT 4a is a potent inhibitor of the toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex. CU CPT 4a shows dose-dependent inhibitory effects blocking Poly (I:C)-induced TLR3 activation with an IC50 of 3.44 µM[1][2].
N-Benzoyl-2′-O-2-propyn-1-yladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
Binetrakin (Interleukin 4 (human)) is a T lymphocyte-derived pleiotrophic cytokine that affects a variety of cell types including B cells and T cells. Binetrakin induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Binetrakin can be used for the research of many biological[1][2].
Soyasaponin IV, isolated from the aerial parts of Glycine soya, exhibits a hepatoprotective action[1].
Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent[1][2].
HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. IC50 value: 28 nM [2]Target: ATXin vitro: HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation. [1]in vivo: HA130 instantaneously lowers plasma levels of LPA in mice after intravenous administration. HA130 is an inhibitor of the enzymatic activity of ATX, slows T cell migration across lymph node HEVs. HA130 decreased the "outside HEVs/inside HEVs" ratio by 3-4-fold, compared to vehicle-treated animals vehicle (p < 0.01 for both PLNs and MLNs). [1]
Fosmetpantotenate is a phosphopantothenic acid (PPA) prodrug designed to release PPA intracellularly, leading to restoration of CoA levels. Fosmetpantotenate is used to treat pantothenate kinase-associated neurodegeneration.
Antifungal agent 24 (Compound 6) is an antifungal agent against Candida albicans with a MIC value of 0.03 μg/mL[1].
PKI (14-24)amide TFA is a potent PKA inhibitor. PKI (14-24)amide strongly inhibited cyclic AMP-dependent protein kinase activity in the cell homogenate[1][2].
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic[1].
Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC50 values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe[1].
3-Azido-L-alanine hydrochloride is an aliphatic functionalized amino acid with side chain lengths of up to four carbons[1].
Glycidyl stearate-d5 is a deuterium labeled Glycidyl stearate (HY-W011188). Oxiran-2-ylmethyl stearate is a compound belonging to the class of esters. It contains reactive oxirane or epoxy groups that give the molecule its unique properties. Oxiran-2-ylmethyl stearate is derived from stearic acid and epichlorohydrin, which are naturally occurring substances. Glycidyl stearate is commonly used in various industrial applications such as the production of coatings, adhesives and surfactants. It can also be used as a crosslinking agent in the manufacture of polymers and resins.
OfChi-h-IN-2 (compound TQ19) is a potent OfChi-h inhibitor with a Ki value of 0.33 μM. OfChi-h-IN-2 can significantly inhibit the growth and development of Ostrinia nubilalis larvae. OfChi-h-IN-2 can be used in agricultural insecticide research[1].
Nilutamide (Nilandron) is a non-steroidal anti-androgen drug proposed in the treatment of metastatic prostatic carcinoma[1][2].
Pinacidil is a potent activator of potassium channel. Pinacidil is an antihypertensive agent which hyperpolarises vascular smooth muscle by opening K+-channels. Pinacidil significantly improves the reperfusion function and cardiac compliance. Pinacidil has direct cardioprotective efficacy[1].
DL-methionine methylsulfonium chloride is a naturally occurring methionine derivative. DL-methionine methylsulfonium chloride protects gastric mucosal from ethanol-induced damage[1].
Aliskiren D6 Hydrochloride is is deuterium labeled Aliskiren, which is a direct renin inhibitor with IC50 of 1.5 nM.
CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation[1].
Methyl N-methylanthranilate, a terpene, is a pungent compound that can be found in Citrus reticulate Blanco leaves. Methyl N-methylanthranilate has the potential for pain research[1].
S-Benzyl-L-cysteinol is a cysteine derivative[1].
Menin-MLL inhibitor 21(example 9) is a specific irreversible inhibitor of Menin-MLL interactions and can be used in the study of autoimmune diseases, alloimmune diseases, cancer and other diseases dependent on menin-MLL[1].