Nilutamide

Modify Date: 2025-08-22 23:49:20

Nilutamide Structure
Nilutamide structure
Common Name Nilutamide
CAS Number 63612-50-0 Molecular Weight 317.221
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C12H10F3N3O4 Melting Point 1490C
MSDS Chinese USA Flash Point N/A
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger

 Use of Nilutamide


Nilutamide (Nilandron) is a non-steroidal anti-androgen drug proposed in the treatment of metastatic prostatic carcinoma[1][2].

 Names

Name nilutamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Melting Point 1490C
Molecular Formula C12H10F3N3O4
Molecular Weight 317.221
Exact Mass 317.062347
PSA 95.23000
LogP 2.23
Index of Refraction 1.524
InChIKey XWXYUMMDTVBTOU-UHFFFAOYSA-N
SMILES CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O
Storage condition Store at RT

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI9453300
CHEMICAL NAME :
2,4-Imidazolidinedione, 5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-
CAS REGISTRY NUMBER :
63612-50-0
BEILSTEIN REFERENCE NO. :
0841906
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C12-H10-F3-N3-O4
MOLECULAR WEIGHT :
317.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
195 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,763,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,763,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,763,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,763,1987 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
375 mg/kg
SEX/DURATION :
male 15 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 42,121,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 42,121,1990

 Safety Information

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301-H360
Precautionary Statements P201-P301 + P310-P308 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R60;R25
Safety Phrases 53-36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS NI9453300
HS Code 2933990090

 Synthetic Route

~%

Nilutamide Structure

Nilutamide

CAS#:63612-50-0

Literature: US2012/142937 A1, ; Page/Page column 7 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles32

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Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds.

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High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.

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 Synonyms

MFCD00864670
2,4-Imidazolidinedione, 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
Nilandron
Nilandrone
5,5-Dimethyl-3-[4-nitro-3-(trifluormethyl)phenyl]imidazolidin-2,4-dion
5,5-diméthyl-3-[4-nitro-3-(trifluorométhyl)phényl]imidazolidine-2,4-dione
Nilutamide
Anandron
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
Nilutamida
5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
Nilutamidum
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