Name | [4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acid |
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Synonyms |
MPP dihydrochloride
B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]boronic Acid 3-[(4-{[3-(4-fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden]methyl}phenoxy)methyl]benzeneboronic acid HA 150 HA130 |
Description | HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. IC50 value: 28 nM [2]Target: ATXin vitro: HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation. [1]in vivo: HA130 instantaneously lowers plasma levels of LPA in mice after intravenous administration. HA130 is an inhibitor of the enzymatic activity of ATX, slows T cell migration across lymph node HEVs. HA130 decreased the "outside HEVs/inside HEVs" ratio by 3-4-fold, compared to vehicle-treated animals vehicle (p < 0.01 for both PLNs and MLNs). [1] |
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Related Catalog | |
References |
Molecular Formula | C24H19BFNO5S |
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Molecular Weight | 463.28600 |
Exact Mass | 463.10600 |
PSA | 112.37000 |
LogP | 3.25890 |
Storage condition | 2-8℃ |
~64% 1229652-21-4 |
Literature: Journal of Medicinal Chemistry, , vol. 53, # 13 p. 4958 - 4967 |
Precursor 1 | |
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DownStream 0 |