1858268-66-2

1858268-66-2 structure

Name: Fosmetpantotenate
Chemical Name: Fosmetpantotenate
CAS Number: 1858268-66-2
Molecular Formula: C₂₀H₃₁N₂O₉P
Molecular Weight: 474.44
Catalog: Research Areas Neurological Disease
Create Date: 2022-03-26 20:22:22
Modify Date: 2025-08-21 19:43:46
Fosmetpantotenate is a phosphopantothenic acid (PPA) prodrug designed to release PPA intracellularly, leading to restoration of CoA levels. Fosmetpantotenate is used to treat pantothenate kinase-associated neurodegeneration.

Name	Fosmetpantotenate

Description	Fosmetpantotenate is a phosphopantothenic acid (PPA) prodrug designed to release PPA intracellularly, leading to restoration of CoA levels. Fosmetpantotenate is used to treat pantothenate kinase-associated neurodegeneration.
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Elbaum D, Beconi MG, Monteagudo E, et al. Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models. PLoS One. 2018;13(3):e0192028. Published 2018 Mar 9. [2]. Klopstock T, Escolar ML, Marshall RD, et al. The FOsmetpantotenate Replacement Therapy (FORT) randomized, double-blind, Placebo-controlled pivotal trial: Study design and development methodology of a novel primary efficacy outcome in patients with pantothenate kinase-associated neurodegeneration. Clin Trials. 2019;16(4):410-418.

Molecular Formula	C₂₀H₃₁N₂O₉P
Molecular Weight	474.44