Tiamulin is a diterpenic veterinary drug widely used in swine for the control of infectious diseases, including swine dysentery and enzootic pneumonia.
Dansyl chloride-d6 is the deuterium labeled 3-Mercapto-3-methylbutan-1-ol[1].
Thiamphenicol is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol.Target: AntibacterialThiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Morocco and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia. Thiamphenicol is a derivative of chloramphenicol characterized by a spectrum comparable to that of the parent compound against multiresistant pathogens but showing satisfactory tolerability. Thiamphenicol showed a significant PAE (0.33 to 2.9h) on all pathogens studied and a powerful bactericidal effect against beta-lactamase-positive and -negative H. influenzae. These results indicate a good in vitro activity of thiamphenicol against difficult-to-treat multiply resistant pathogens [1, 2].
Pheniprazine hydrochloride is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression[1].
Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].
17:0-18:1 PI-d5 (ammonium) is deuterium labeled 17:0-18:1 PI (ammonium).
RORγt inverse agonist 23 is a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
Thiazole Orange is a dye for reticulocyte analysis.
(R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) is an anticholinergic agent. (R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) has the ability to reduce the frequency of drooling in vivo with developmental disabilities[1].
Efrilacedase alfa is an active compound. Efrilacedase alfa can be used for various biochemical studies.
Opinercept is a tumor necrosis factor-alpha (TNF-alpha) inhibitor. Opinercept can be used for the research of rheumatoid arthritis (RA)[1].
ATTO 488 is a new type of fluorescent dye with high fluorescence yield, which can be used for most labeling applications, maximum excitation/emission wavelength: 500/520 nm.
DACN(Tos,Ns) is a click chemistry reagent containing an azide group[1].
4,4,4,4',4',4'-Hexafluoro-DL-valine is a valine derivative[1].
Valtorcitabine dihydrochloride is a prodrug of L-deoxycytidine and also is an HBV inhibitor[1].
Tinengotinib is the modulator of one or more protein kinases such as Aurora kinase and VEGFR kinase. Tinengotinib has the potential for the research of these kinase abnormalities diseases mediated, especially cancer-related diseases (extracted from patent WO2018108079A1)[1].
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2].
neo-Inositol, a stereoisomer of inositol, has been isolated from calf brain[1].
Mogroside IV, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities[1].
D-Pantothenic acid hemicalcium salt, a kind of water solublevitamin, can reduce the patulin content of the apple juice.IC50 value:Target:In vitro: In human dermal fibroblasts from three different donors, D-Pantothenic acid hemicalcium salt accelerates the wound healing process by increasing the number of migrating cells, their distance and hence their speed. In addition, cell division is increased and the protein synthesis changed [1].In vivo:
N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683). The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone[1].
Ceftiofur hydrochloride is a semisynthetic antibiotic, with activity against various gram-positive and gram-negative, aerobic and anaerobic bacteria encountered by domestic animals[1].
TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM)[1].
1,3-Propanediol-d6 is the deuterium labeled 1,3-Propanediol[1]. 1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism[2].
Trepibutone (AA 149) increases secretion of bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract. Trepibutone can be used for the research of cholecystitis and functional gastrointestinal disorders[1][2].
Methyl (3α,5α)-3-(acetyloxy)-6-oxocholan-24-oate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Spiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α，5-HT1β and 5-HT2，respectively. Spiroxatrine (R 5188) has a sedative effect[1][2][3][4].
Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates[1][2].
Clibucaine is a piperidine derivative possessing local anesthetic properties. Clibucaine can be used as a local anesthetic agent[1].