101526-83-4

101526-83-4 structure

Name: Sematilide
Chemical Name: N-[2-(diethylamino)ethyl]-4-(methanesulfonamido)benzamide
CAS Number: 101526-83-4
Molecular Formula: C₁₄H₂₃N₃O₃S
Molecular Weight: 313.41600
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-09-08 19:38:07
Modify Date: 2024-01-10 09:19:41
Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].

Name	N-[2-(diethylamino)ethyl]-4-(methanesulfonamido)benzamide
Synonyms	C14H23N3O3S UNII-0NHB13IN3R Sematilide

Description	Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 25 μM (K+ current)[1]
In Vitro	Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1].
In Vivo	Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia[2]. Animal Model: Mongrel dogs of either sex (10-18 kg body weight)[2] Dosage: 0.3, 1, 3, and 10 mg/kg Administration: I.v. infusions Result: Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
References	[1]. Ishii Y, et al. Effects of Sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Eur J Pharmacol. 1997 Jul 23;331(2-3):295-302. [2]. Stanley S. Greenberg, et al. Pharmacology of Sematilide, a non-quaternary class III antiarrhythmic agent.

HS Code	2935009090

50790-28-8

100-36-7

101526-83-4

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%