NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1].
BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing[1].
Fmoc-β-cyclopropyl-L-Alanine is an alanine derivative[1].
NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 is an substrate for hydrolysis of the matrix metalloproteinase stromelysin (MMP-3) and can be easily detected at Abs/Em=350/465 nm[1].
Angustin A (1,8-Dihydroxy-4,6,7-trimethoxyxanthone) is a xanthones that can be isolated from the aerial parts of Swertia angustifolia[1].
Lenperone (AHR 2277 free?base) has antipsychotic effect. Lenperone improves depressive symptoms[1].
O-Geranylconiferyl alcohol is a sesquiterpenoids? isolated from? the root of Ligularia duciformis[1].
Taltobulin intermediate-2 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].
DpC is an anti-tumor agent. DpC inhibits cancer cell proliferation (IC50: 0.007-0.096 渭M). DpC synergizes with multiple anti-cancer therapeutics[1].
Potassium tert-butyl malonate is an intermediate in the synthesis of malonate monoester potassium salt[1].
Eburicoic acid protects the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms[1]. And Eburicoic acid has antidiabetic and antihyperlipidemic effects[2].
Eucalyptin is a flavonoid. Eucalyptin can be isolated from Myrcia citrifolia[1].
Fmoc-Lys(Fmoc)-OH is a lysine derivative[1].
Iopanoic acid is an inhibitor of 5'-Deiodinase and also an iodinated contrast medium.
GADGVGKSAL is a mutant KRAS G12D 10mer peptide. GADGVGKSAL can be used as an immunogenic neoantigen for cancer immunotherapy research[1].
PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively; displays good selectivity over dopamine reuptake inhibition (DRI) (IC50=544 nM); possesses good in vitro metabolic stability, weak CYP inhibition and drug-like physicochemical properties consistent with CNS target space.
BCL6 ligand-1 (compound I-94) is a ligand for TCIP 1 (HY-156531). TCIP 1 is a BCL6 inhibitor that activates apoptosis and is used in cancer research[1].
11-Keto fusidic acid shows strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL.
L-Xylose-2-13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
Vinorine is a compound isolated from the bark of Rauvolfia reflexa[1].
Boc-Glu(OBzl)-Gly-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1].
Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles[1][2].
Ethyl (4-(trifluoromethoxy)phenyl)glycinate is a Glycine (HY-Y0966) derivative[1].
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects[1].
Acetylexidonin is a diterpenoid compound with anti-inflammation and cancer activity. Acetylexidonin inhibits tumor cells with IC50s of 3.69 μM (NB4) and 26.22 μM (SHSY5Y), respectively[1].
Phenylthiourea (Phenylthiocarbamide) is an inhibitor of phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki: 0.21?μM)[1].
(-)-Variabilin (compound 13) is an Neurogenin2 (Ngn2) promoter activator isolated from Butea superba. (-)-Variabilin promotes differentiation of neural stem cells into neurons[1].
Ganoderenic acid C is a triterpenoid isolated from Ganoderma lingzhi. Ganoderenic acid C is abundant in fruit bodies at an early growth stage[1].
Tetrakis (4-carboxyphenyl) porphyrin (TCPP) plays the role of a metal remover[1].
Alpha-cyperone is associated with the down-regulation of COX-2,IL-6,Nck-2,Cdc42 and Rac1, resulting in reduction of inflammation. which would be highly beneficial for treatment of inflammatory diseases such as AD.In vitro: The anti-inflammatory activity of alpha-cyperone is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells.[1]Alpha-Cyperone binds and interacts with tubulin and is capable of distinctly destabilizing microtubule polymerization. The effect of this interaction could result in reduction of inflammation which would be highly beneficial for treatment of inflammatory diseases such as AD. One microliter of alpha-Cyperone was dissolved in DMSO (1:1 v/v) and it was further diluted in double distilled water (ddH2O) to a final volume of 20 microliter. [2]