DPC

Modify Date: 2024-01-11 11:46:36

DPC Structure
DPC structure
Common Name DPC
CAS Number 1382469-39-7 Molecular Weight 353.48
Density 1.2±0.1 g/cm3 Boiling Point 510.7±48.0 °C at 760 mmHg
Molecular Formula C19H23N5S Melting Point N/A
MSDS USA Flash Point 262.7±29.6 °C
Symbol GHS06
GHS06
Signal Word Danger

 Names

Name DPC
Synonym More Synonyms

 DPC Biological Activity

Description DpC is an anti-tumor agent. DpC inhibits cancer cell proliferation (IC50: 0.007-0.096 渭M). DpC synergizes with multiple anti-cancer therapeutics[1].
Related Catalog
References

[1]. Dharmasivam M, et al. The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells. Biochim Biophys Acta Gen Subj. 2022 Aug;1866(8):130152.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 510.7±48.0 °C at 760 mmHg
Molecular Formula C19H23N5S
Molecular Weight 353.48
Flash Point 262.7±29.6 °C
Exact Mass 353.167419
LogP 3.27
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.649
Storage condition 20°C

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes T
RIDADR UN 2811 6.1 / PGIII

 Articles2

More Articles
The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

Oncotarget 6 , 8851-74, (2015)

N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that plays a key role in regulating signaling pathways involved in mediating cancer cell invasion and migration, including t...

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.

J. Biol. Chem. 291 , 1029-52, (2016)

N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-β pa...

 Synonyms

DI-2-PYRIDYLKETONE 4-CYCLOHEXYL-4-METHYL-3-THIOSEMICARBAZONE
N-Cyclohexyl-2-(di-2-pyridinylmethylene)-N-methylhydrazinecarbothioamide
Hydrazinecarbothioamide, N-cyclohexyl-2-(di-2-pyridinylmethylene)-N-methyl-
DPC
Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone
MFCD22666593