DpC

Names

[ Name ]:
DpC

[Synonym ]:
DI-2-PYRIDYLKETONE 4-CYCLOHEXYL-4-METHYL-3-THIOSEMICARBAZONE
N-Cyclohexyl-2-(di-2-pyridinylmethylene)-N-methylhydrazinecarbothioamide
Hydrazinecarbothioamide, N-cyclohexyl-2-(di-2-pyridinylmethylene)-N-methyl-
DPC
Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone
MFCD22666593

Biological Activity

[Description]:

DpC is an anti-tumor agent. DpC inhibits cancer cell proliferation (IC50: 0.007-0.096 渭M). DpC synergizes with multiple anti-cancer therapeutics[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Dharmasivam M, et al. The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells. Biochim Biophys Acta Gen Subj. 2022 Aug;1866(8):130152.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
510.7±48.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₃N₅S

[ Molecular Weight ]:
353.48

[ Flash Point ]:
262.7±29.6 °C

[ Exact Mass ]:
353.167419

[ LogP ]:
3.27

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
20°C

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
T

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

Oncotarget 6 , 8851-74, (2015)

N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that plays a key role in regulating signaling pathways involved in mediating cancer cell invasion and migration, including t...

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.

J. Biol. Chem. 291 , 1029-52, (2016)

N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-β pa...

Related Compounds

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