Dexelvucitabine

Modify Date: 2024-01-08 19:20:37

Dexelvucitabine structure	Common Name	Dexelvucitabine
	CAS Number	134379-77-4	Molecular Weight	227.19200
	Density	1.66g/cm3	Boiling Point	394.9ºC at 760mmHg
	Molecular Formula	C₉H₁₀FN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	192.6ºC

Use of Dexelvucitabine

Dexelvucitabine (Reverset; d-d4FC), a Cytidine (HY-B0158) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful drug against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent[1].

Name	4-amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one
Synonym	More Synonyms

Description	Dexelvucitabine (Reverset; d-d4FC), a Cytidine (HY-B0158) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful drug against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	HIV-1
In Vivo	Dexelvucitabine (Reverset; d-d4FC; 33.3 mg/kg by i.v. or p.o.) has distribution and elimination half-lives (t1/2α and t1/2β, respectively) of 0.7 and 3.6 h in monkeys, respectively. The Cmax ranges from 21.1 to 47.5 μM[2]. Dexelvucitabine has a favorable pharmacokinetic profile with a long half-life (4.71 and 10.75 h after administration by the intravenous [i.v.] and oral [p.o.] routes, respectively) in woodchucks[2].
References	[1]. Brenda I Hernandez-Santiago, et al. Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine. Antimicrob Agents Chemother. 2007 Jun;51(6):2130-5. [2]. L Ma, et al. Pharmacokinetics of the antiviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys. Antimicrob Agents Chemother. 1999 Feb;43(2):381-4.

Density	1.66g/cm3
Boiling Point	394.9ºC at 760mmHg
Molecular Formula	C₉H₁₀FN₃O₃
Molecular Weight	227.19200
Flash Point	192.6ºC
Exact Mass	227.07100
PSA	90.37000
Vapour Pressure	7.15E-08mmHg at 25°C
Index of Refraction	1.665
Storage condition	2-8°C

Precursor 5
CAS#:869383-89-1 4-methoxybenzoi... CAS#:20031-21-4 1,2-O-Isopropyl... CAS#:869496-59-3 1,4-anhydro-3',... CAS#:869383-87-9 1,2-O-isopropyl...
CAS#:6893-67-0 1,2-O-isopropyl...
DownStream 2
CAS#:98-00-0 Furfuryl alcohol CAS#:2022-85-7 5-Flucytosine