Phenylthiocarbamide

Modify Date: 2024-01-02 20:12:12

Phenylthiocarbamide structure	Common Name	Phenylthiocarbamide
	CAS Number	103-85-5	Molecular Weight	152.217
	Density	1.3±0.1 g/cm3	Boiling Point	266.7±23.0 °C at 760 mmHg
	Molecular Formula	C₇H₈N₂S	Melting Point	145-150 °C(lit.)
	MSDS	Chinese USA	Flash Point	115.1±22.6 °C
	Symbol	GHS06	Signal Word	Danger

Use of Phenylthiocarbamide

Phenylthiourea (Phenylthiocarbamide) is an inhibitor of phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki: 0.21?μM)[1].

Name	N-phenylthiourea
Synonym	More Synonyms

Description	Phenylthiourea (Phenylthiocarbamide) is an inhibitor of phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki: 0.21?μM)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	phenoloxidase[1]
References	[1]. Ryazanova AD, et al. The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase. J Enzyme Inhib Med Chem. 2012 Feb;27(1):78-83.

Density	1.3±0.1 g/cm3
Boiling Point	266.7±23.0 °C at 760 mmHg
Melting Point	145-150 °C(lit.)
Molecular Formula	C₇H₈N₂S
Molecular Weight	152.217
Flash Point	115.1±22.6 °C
Exact Mass	152.040817
PSA	70.14000
LogP	0.73
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.725
Storage condition	Poison room
Stability	Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.

Phenylthiocarbamide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU1400000

CHEMICAL NAME :: Urea, 1-phenyl-2-thio-

CAS REGISTRY NUMBER :: 103-85-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C7-H8-N2-S

MOLECULAR WEIGHT :: 152.23

WISWESSER LINE NOTATION :: SUYZMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Endocrine - hyperglycemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 168 mg/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - other effects to embryo

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 8 mmol/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0839 No. of Facilities: 54 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 2415 (estimated) No. of Female Employees: 483 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H317
Precautionary Statements	P264-P280-P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+
Risk Phrases	R28
Safety Phrases	S28-S36/37-S45
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	YU1400000
Packaging Group	I
Hazard Class	6.1
HS Code	2930909090

Precursor 7
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HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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N′-phenylthiourea

N-phenylthiourea

PTU

1-Phenylthiourea

EINECS 203-151-2

Thiourea, N-phenyl-

MFCD00004933

Phenylthiocarbamide

1-PHENYL-2-THIOUREA

Phenylthiourea

PTC

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Phenylthiocarbamide
Price: ￥138.0/25g ￥428.0/100g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Phenyl-2-thiourea
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: tianfu-chem_1-Phenyl-2-thiourea 103-85-5
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥110/10 mM * 1 mL in DMSO

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Phenylthiocarbamide

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