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103-85-5

103-85-5 structure
103-85-5 structure
  • Name: Phenylthiocarbamide
  • Chemical Name: N-phenylthiourea
  • CAS Number: 103-85-5
  • Molecular Formula: C7H8N2S
  • Molecular Weight: 152.217
  • Catalog: Chemical reagent Organic reagent Thiourea
  • Create Date: 2018-09-18 16:43:50
  • Modify Date: 2025-08-20 12:40:44
  • Phenylthiourea (Phenylthiocarbamide) is an inhibitor of phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki: 0.21?μM)[1].
Name N-phenylthiourea
Synonyms N′-phenylthiourea
N-phenylthiourea
PTU
1-Phenylthiourea
EINECS 203-151-2
Thiourea, N-phenyl-
MFCD00004933
Phenylthiocarbamide
1-PHENYL-2-THIOUREA
Phenylthiourea
PTC
Description Phenylthiourea (Phenylthiocarbamide) is an inhibitor of phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki: 0.21?μM)[1].
Related Catalog
Target

phenoloxidase[1]

References

[1]. Ryazanova AD, et al. The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase. J Enzyme Inhib Med Chem. 2012 Feb;27(1):78-83.  

Density 1.3±0.1 g/cm3
Boiling Point 266.7±23.0 °C at 760 mmHg
Melting Point 145-150 °C(lit.)
Molecular Formula C7H8N2S
Molecular Weight 152.217
Flash Point 115.1±22.6 °C
Exact Mass 152.040817
PSA 70.14000
LogP 0.73
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.725
Storage condition Poison room
Stability Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU1400000
CHEMICAL NAME :
Urea, 1-phenyl-2-thio-
CAS REGISTRY NUMBER :
103-85-5
LAST UPDATED :
199710
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C7-H8-N2-S
MOLECULAR WEIGHT :
152.23
WISWESSER LINE NOTATION :
SUYZMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Endocrine - hyperglycemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
168 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - other effects to embryo

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
8 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0839 No. of Facilities: 54 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 2415 (estimated) No. of Female Employees: 483 (estimated)
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300-H317
Precautionary Statements P264-P280-P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T+
Risk Phrases R28
Safety Phrases S28-S36/37-S45
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS YU1400000
Packaging Group I
Hazard Class 6.1
HS Code 2930909090
HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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