5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate)[1].
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A)[1].
Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.
Phyllanthin is a major bioactive lignan component of Phyllanthus amarus. Phyllanthin exhibits high antioxidative and hepatoprotective properties[1].
[DAla2] Dynorphin A (1-9) (porcine) is a dynorphin, which can be used in studies of analgesic, addiction, and depression.
Hosenkoside F is a baccharane glycoside isolated from the seeds of impatiens balsamina.
N-Trifluoroacetyl-L-methionine methyl ester is a Methionine (HY-13694) derivative[1].
Momordicoside K is a cucurbitane triterpenoid[1].
(Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) is a biologically active peptide.
DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles[1].
Tetratriacontane-d70 is the deuterium labeled Tetratriacontane[1].
Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation Process, used for pharmaceuticals.
4-Propylphenol-d12 is the deuterium labeled 4-Propylphenol[1].
11-Oxo-α-amyrin (Neoilexonol) is a triterpenoid that can be isolated from Leonurus japonicus (Lamiaceae)[1].
Agalactoglyco peptide is an peptide. Agalactoglyco peptide can be used for the research of various biochemical[1].
Fmoc-D-Lys(N3)-OH is a click chemistry reagent containing an azide group. Fmoc-D-Lys(N3)-OH can be used for the research of various biochemical[1].
PYBG-TMR is a dye and has a role as a fluorochrome. PYBG-TMR specifically and efficiently labels the target genetically encoded SNAP-tags in live cells[1].
RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].
5,6,7-Trihydroxyflavone-7-O-β-D-glucuronopyranoside is a natural product that can be isolated from the root of Scutellaria repens Buch.-Ham. ex D. Don[1].
Hydroxymethylenetanshiquinone is a abietane diterpene that can inhibits tumor cell proliferation[1].
RVG-Cys (RVG29-Cys) is based on rabies virus glycoprotein (RVG29) peptide and connected to Cys to facilitate subsequent coupling[1].
SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM[1][2].
Bdp tr nhs ester is a chemiluminescent coupling compound with a long excited state lifetime for immunoassays and is suitable for microscopy and fluorescence polarization analysis applications. NHS ester can react specifically and efficiently with the side chains of primary amines such as lysine residues or amino silane coated surfaces under neutral or weakly basic conditions to form covalent bonds[1].
3,5,6,7,8,3',4'-heptamethoxyflavone, a flavonoid in C. unshiu peels, exhibits anti-tumor-initiating effect and Anti-neuroinflammatory activity[1][2][3]. 3,5,6,7,8,3',4'-heptamethoxyflavone inhibits collagenase activity and increased type I procollagen content in HDFn cells[1]. 3,5,6,7,8,3',4'-heptamethoxyflavone induces brain-derived neurotrophic factor (BDNF) expression via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells[4].
Diphtheria toxin CRM197, a nontoxic variant of diphtheria toxin, has a single mutation (Glycine to Glutamate substitution at position 52) that eliminates its toxicity. CRM197 is widely used as a carrier protein in conjugate vaccines[1].
Sodium benzoate can be used as an excipient, such as antimicrobial agent, preservative, lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure[1].
Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion[1].
(R)-2-((tert-Butoxycarbonyl)amino)-3-(3,4-dichlorophenyl)propanoic acid is a phenylalanine derivative[1].
Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C is found to be highly effective against rotavirus replication[2].