313553-47-8

313553-47-8 structure

Name: INH1
Chemical Name: N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]benzamide,hydrochloride
CAS Number: 313553-47-8
Molecular Formula: C₁₈H₁₆N₂OS
Molecular Weight: 308.40
Catalog: Biochemical Inhibitor Cytoskeletal Signaling Microtubule Associated Inhibitor
Create Date: 2019-02-16 16:57:40
Modify Date: 2024-01-02 16:50:02
INH1 is a small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.IC50 value: 10-21 uM (GI50 in human breast cancer cell lines) [1]Target: Hec1 inhibitorTreating cells with INH1 triggered reduction of kinetochore-bound Hec1 as well as global Nek2 protein level, consequently leading to metaphase chromosome misalignment, spindle aberrancy, and eventual cell death. INH1 effectively inhibited the proliferation of multiple human breast cancer cell lines in culture (GI(50), 10-21 micromol/L). Furthermore, treatment with INH1 retarded tumor growth in a nude mouse model bearing xenografts derived from the human breast cancer line MDA-MB-468, with no apparent side effects. This study suggests that the Hec1/Nek2 pathway may serve as a novel mitotic target for cancer intervention by small compounds.

Name	N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]benzamide,hydrochloride
Synonyms	Benzamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]benzamide Y0392 INH1 N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride

Description	INH1 is a small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.IC50 value: 10-21 uM (GI50 in human breast cancer cell lines) [1]Target: Hec1 inhibitorTreating cells with INH1 triggered reduction of kinetochore-bound Hec1 as well as global Nek2 protein level, consequently leading to metaphase chromosome misalignment, spindle aberrancy, and eventual cell death. INH1 effectively inhibited the proliferation of multiple human breast cancer cell lines in culture (GI(50), 10-21 micromol/L). Furthermore, treatment with INH1 retarded tumor growth in a nude mouse model bearing xenografts derived from the human breast cancer line MDA-MB-468, with no apparent side effects. This study suggests that the Hec1/Nek2 pathway may serve as a novel mitotic target for cancer intervention by small compounds.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Wu G, et al. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008 Oct 15;68(20):8393-9.