862090-74-2

862090-74-2 structure

Name: Chymase-IN-1
Chemical Name: Chymase-IN-1
CAS Number: 862090-74-2
Molecular Formula: C₂₀H₁₅ClNO₄PS
Molecular Weight: 431.83
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-05-18 09:47:17
Modify Date: 2024-01-10 11:08:01
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.

Name	Chymase-IN-1

Description	Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 29 nM (chymase)[1]
In Vitro	Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
In Vivo	Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].
References	[1]. Greco MN, et al. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.