Canosimibe is a cholesterol absorption inhibitor extracted from patent WO2004087655A1.
12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1].
HCT-116-IN-1, a γ-lactam-fused pyridone derivative, has anticancer activity and displayed high cytotoxicity against HCT116 cells with an IC50 of 5.59 μM[1].
Migalastat (GR181413A (free base)) is an orally active and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A[1].
Shishijimicin C is a novel antitumor agent found from the Ascidian Didemnum proliferum. Shishijimicin C shows anti-tumor activity with highly potent cytotoxicities[1].
Dansyl chloride-13C2 is the 13C labeled Dansyl chloride[1].
Sodium carbonate,99.999% metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
o-Tolyl-Isocyanated7 is the deuterium labeled o-Tolyl-Isocyanate[1].
(+)-Secoisolariciresinol, a lignan compound, is a (+)-enantiomer of Secoisolariciresinol[1].
H-Lys-Gly-OH is a biologically active peptide.
N-Desmethyl Imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR.
Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity[1].
Epimedin B1 is initially isolated from E. Wushanense and is a Chemical marker of E. sagittatum in drug Yin-Yang-Huo. Epimedin B1 is the isomer of Epimedin B[1].
Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro[1]. Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.
Suc-Phe-Leu-Phe-4MβNA is a fluorescent peptide substrate[1].
(Des-Ser3)-ACTH (1-24) (human, bovine, rat) is a peptide analog of the adrenocorticotropic hormone (ACTH). ACTH stimulates the production of cortisol[1].
N-(4-Nitrobenzoyl)-L-glutamic acid diethyl ester is a glutamic acid derivative[1].
Oblongine is isolated from the tuber of Stephania cambodica.
Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).
Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].
Lotusine is a pure alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn. Lotusine shows effects on the action potentials in myocardium and slow inward current in cardiac Purkinje fibers[1].
Demethylwedelolactone Sulfate (Demethylwedelolactone 3-sulfate) is a coumestan isolated from Eclipta prostrata L.[1].
MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor. MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression[1].
Trimethyl phosphate-d9 is the deuterium labeled Trimethyl phosphate[1].
Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome(λex=495 nm, λem=520 nm). Sequence: Ala-{d-Thr}-Cys-{Hyp}-Ala-Trp-Leu (Disulfide bridge: Cys3-Cys6);A-{d-Thr}-C-{Hyp}-AWL (Disulfide bridge: Cys3-Cys6).
Hexa-N-acetylchitohexaose is an inducer of disease resistance in crop plants, which could elicit an increase of lignification-related and antioxidative enzymes in soybean plants. Hexa-N-acetylchitohexaose is a substrate of lysozyme. Hexa-N-acetylchitohexaose shows antitumor effect[1][2][3].
Cynatratoside A, an oligoglycoside, is a nature product that could be isolated from the roots of Cynanchum paniculatum[1].
Xanthone V1a has antioxidant activity against the DPPH radical (IC50: 10.43 µM). Xanthone V1a has cytotoxicity against cancer cells[1][2].
Danshenxinkun D is an anti-Alzheimer's disease (AD) candidate. Danshenxinkun D can significantly reverse the expression of PSEN1 and DRD2 mRNA in H2O2 treated PC12 cells. Danshenxinkun D can be used in the study of anti-Alzheimer's disease product candidate [1].